ArticleBreast cancer (Dove Medical Press)2026
Peripheral Blood IL-6 and STAT3 Gene Expression as Biomarkers Associated with Neoadjuvant Chemotherapy Response in Triple-Negative Breast Cancer: A Prospective Cross-Sectional Study.
Article in Breast cancer (Dove Medical Press), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Purpose: Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited targeted treatment options. Blood-based biomarkers that might help predict response to neoadjuvant chemotherapy (NAC) remain lacking. We examined whether pre-treatment peripheral blood expression of interleukin-6 (IL-6) and signal transducer and activator of transcription 3 (STAT3) was associated with clinicopathological features and NAC response in TNBC. Methods: This prospective cross-sectional study included 20 patients with TNBC and 10 healthy controls. Whole-blood RNA was isolated using Trizol, reverse-transcribed to cDNA, and analysed by RT-qPCR with TaqMan Results: Compared with the control group, IL-6 and STAT3 expression levels were significantly elevated in patients with TNBC by 8.9-fold ( Conclusion: In this pilot cohort, higher peripheral blood IL-6 and STAT3 expression was associated with unfavourable clinicopathological features in TNBC. These findings suggest that the IL-6/STAT3 axis may have value within broader predictive biomarker panels, although larger prospective studies are needed before any clinical application is considered.
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