Evidence map›Paper›PMID 41978643›Full record

ArticleNeuro-oncology pediatrics2026

FOXR2-activated CNS neuroblastoma: Characterized by variable structural disruption of the

Jianling Ji, Venkata Yellapantula, Dong Xu, Dolores Estrine, Alexander Markowitz, Jennifer Han, Katherine Ma, Cindy Fong, Debra Hawes, Ashley Margol and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. "Updates on diagnostic and prognostic molecular biomarkers of CNS tumors".Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jianling JiDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, United States.ORCID https://orcid.org/0000-0003-4941-3538
Venkata YellapantulaDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Dong Xu
Dolores EstrineDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Alexander Markowitz
Jennifer HanDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Katherine Ma
Cindy FongDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Debra HawesDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Ashley MargolORCID https://orcid.org/0000-0002-3038-8005
Katrina O'Halloran
Nathan J RobisonDepartment of Pediatrics, Keck School of Medicine of University of Southern CA, Los Angeles, CA, United States.
Jaclyn A BiegelDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Jennifer A CotterDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, United States.ORCID https://orcid.org/0000-0002-1420-3314
Gordana RacaDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Jessica W TsaiDepartment of Pediatrics, Keck School of Medicine of University of Southern CA, Los Angeles, CA, United States.ORCID https://orcid.org/0000-0003-0540-4330

Funding

Dissecting the cooperation of FOXR2 and ETS transcription factors in FOXR2-expressing diffuse midline gliomasK08CA279908 · NCI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Jessica Whei Tsai · 2024 to 2026
$789k
NCI NIH HHS K08 CA279908
6 · The paper itself

Abstract

Background: FOXR2 is a forkhead box transcription factor implicated in central nervous system neuroblastoma (CNS-NB FOXR2). The underlying genetic mechanisms and clinical features of CNS-NB FOXR2 have yet to be elucidated. Methods: Six CNS-NB FOXR2 cases were identified through DNA methylation profiling. Optical genome mapping, chromosomal microarray, whole genome sequencing, OncoKids panel, RNA sequencing (RNA-seq), and clinical data were analyzed. Results: Case 1 demonstrated a 13-kb insertion approximately 25 kb upstream of Conclusions: Structural disruption of the

Indexed as

CNS neuroblastomacopy number abnormalityFOXR2methylation profilingoptical genome mapping

Identifiers

PMID41978643
PMCPMC13070476

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.