ArticleInfection and drug resistance2026
Sociodemographic and Clinical Correlates of Multidrug-Resistant Uropathogens in Hospitalized Children.
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Antibiotic resistance in uropathogens causing urinary tract infections (UTIs) is increasing; nonetheless, evidence on multidrug-resistant (MDR) bacteria remains limited. We aimed to examine the prevalence and risk factors of Gram-negative MDR bacteria in pediatric UTIs and compared the hospitalization duration and cost between patients with and without MDR. Patients and Methods: A retrospective single-center study was conducted among hospitalized children from 2015 to 2020. Sociodemographic (age, sex, population group, residential socioeconomic status), clinical (prior hospitalizations, antibiotic use, background diseases), and laboratory (complete blood count, C-reactive protein levels) data were collected from medical files. MDR was defined as non-susceptibility to ≥1 agent in ≥3 antimicrobial classes. Results: The study included 506 children (81.8% girls; median age 11 months). Most (94.2%) isolates were Gram-negative. Resistance to ampicillin, trimethoprim/sulfamethoxazole, amoxicillin/clavulanic acid, nitrofurantoin, cefuroxime-axetil, and cefuroxime-sodium was 33.8%, 12.4%, 9.4%, 3.9%, 3.2%, and 2.5%, respectively. MDR prevalence was 6.9% (95% CI 4.8-9.5), and 50.8% (46.4-55.4) showed resistance/intermediate susceptibility to 1-2 antibiotic categories. Arab children had an increased likelihood of MDR (OR=3.29 (95% CI 1.49-7.25) than Jewish children, and children with vs. without a history of antibiotic use before hospitalization (5.06, 1.67-15.31). The likelihood of resistance/intermediate susceptibility to 1-2 antibiotic categories increased in relation to antibiotic use before hospitalization (2.68, 1.25-5.74) and in males vs. females (1.71, 0.99-2.94). No significant differences were found in hospitalization duration or cost between the MDR groups. Conclusion: The prevalence of MDR and non-susceptibility/resistance to 1-2 antibacterial categories in Gram-negative uropathogens is concerning. Our findings underscore the need for tailored empirical therapy and targeted antibiotic stewardship interventions.
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