ArticlePNAS nexus2026
Implant-derived titanium particles impair macrophage bacterial clearance via TRPC1 and lysosomal dysfunction.
Article in PNAS nexus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
Abstract
Peri-implantitis (PI) is a treatment-resistant inflammatory condition that affects millions of patients with dental implants, leading to destructive loss of jawbone, implant failure, and escalating healthcare costs. It is classically attributed to bacterial biofilms; however, unlike periodontitis, it frequently progresses despite resolution of infection with standard antimicrobial therapy, suggesting a critical gap in our understanding of host-response dysfunction. Here, we identify implant-derived titanium particles (i-TiPs) as a persistent, abiotic pathogenic co-factor that impairs macrophage immune function by disrupting TRPC1-dependent Ca
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