Evidence map›Paper›PMID 41978554›Full record

Trial reportBritish journal of haematology2026

Benefit of selinexor dose reduction on outcomes with selinexor, bortezomib and dexamethasone in patients with lenalidomide-refractory multiple myeloma: Subgroup analysis of the BOSTON trial.

Sosana Delimpasi, Ivan Špička, Jason P Butler, Don A Stevens, Mercedes Gironella Mesa, Ceri Bygrave, Giovanni Marino Merlo, Charles la Porte, Meletios A Dimopoulos

Abstract readClinical Trial, Phase III
In one paragraph

Trial report in British journal of haematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sosana DelimpasiEvangelismos Hospital, Athens, Greece.ORCID https://orcid.org/0000-0001-7523-7510
Ivan ŠpičkaFirst Department of Medicine, Department of Hematology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
Jason P ButlerBone Marrow Transplant Unit, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Don A StevensNorton Cancer Institute, Louisville, Kentucky, USA.
Mercedes Gironella MesaDepartment of Hematology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Ceri BygraveUniversity Hospital of Wales, Cardiff, UK.ORCID https://orcid.org/0000-0002-1571-0692
Giovanni Marino MerloMenarini Group, Florence, Italy.
Charles la PorteMenarini Group, Machelen, Belgium.
Meletios A DimopoulosDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece.

Funding

Menarini Group
6 · The paper itself

Abstract

A subgroup analysis of efficacy, safety and QOL in patients who received selinexor in combination with bortezomib and dexamethasone (SVd) with and without selinexor dose reduction and who had lenalidomide-refractory disease in the phase 3 BOSTON trial showed improvements in efficacy, quality of life (QOL) and safety outcomes with selinexor dose reduction in this difficult-to-treat population. These findings demonstrate the benefit of selinexor dose reductions in optimizing the treatment of patients with lenalidomide-refractory multiple myeloma (MM) receiving SVd.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsMultiple MyelomaAgedBortezomibDexamethasoneDrug Resistance, NeoplasmFemaleHumansHydrazinesLenalidomideMaleMiddle AgedQuality of LifeTreatment OutcomeTriazolesBortezomibDexamethasoneHydrazinesLenalidomideselinexorTriazolesBOSTONdose reductionlenalidomide‐refractorymultiple myelomaselinexor

Identifiers

PMID41978554
PMCPMC13267473

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.