Evidence map›Paper›PMID 41978507›Full record

ArticleInterdisciplinary cardiovascular and thoracic surgery2026

Evaluation of a Novel Multielectrode Surgical Pulsed Field Ablation Clamp: An Ex-Vivo Vegetal Study.

Sanjai Pattu Valappil, Mohamed Abbas, Jonathan Prashanth Ariyaratnam, Chris Robbins, Mohanaraj Jayakumar, Alexis Puvrez, Melanie Anuscha Gunawardene, Michael Kroon, Ian Fong, Ashutosh Hardikar and 2 more

Erratum issuedAbstract readEvaluation Study
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Article in Interdisciplinary cardiovascular and thoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

The trial behind it

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Sanjai Pattu ValappilCentre for Heart Rhythm Disorders, University of Adelaide, Adelaide 5000, Australia.
Mohamed AbbasCentre for Heart Rhythm Disorders, University of Adelaide, Adelaide 5000, Australia.
Jonathan Prashanth AriyaratnamCentre for Heart Rhythm Disorders, University of Adelaide, Adelaide 5000, Australia.
Chris RobbinsCentre for Heart Rhythm Disorders, University of Adelaide, Adelaide 5000, Australia.
Mohanaraj JayakumarCentre for Heart Rhythm Disorders, University of Adelaide, Adelaide 5000, Australia.
Alexis PuvrezCentre for Heart Rhythm Disorders, University of Adelaide, Adelaide 5000, Australia.
Melanie Anuscha GunawardeneCentre for Heart Rhythm Disorders, University of Adelaide, Adelaide 5000, Australia.
Michael KroonCathRx, Sydney 2116, Australia.
Ian FongCathRx, Sydney 2116, Australia.
Ashutosh HardikarDepartment of Cardiothoracic Surgery, Royal Adelaide Hospital, Adelaide 5000, Australia.
Prashanthan SandersCentre for Heart Rhythm Disorders, University of Adelaide, Adelaide 5000, Australia.
Jason VarzalyCentre for Heart Rhythm Disorders, University of Adelaide, Adelaide 5000, Australia.

Funding

University of Adelaide
6 · The paper itself

Abstract

objectivesAt present, there is no commercially available surgical device to perform cardiac ablation utilizing pulsed field ablation (PFA). We sought to explore the efficacy and requirements of a novel PFA clamp to achieve transmural lesions in a vegetal model of Tuberosum Solanum (TS).

methodsWe tested the PFA clamp at different voltages (1400 V, 2000 V, 2800 V) and numbers of applications (2 or 4) on slabs of TS having different thicknesses (10 mm, 20 mm, 30 mm). Each slab was sliced transversally and the halves put together or kept whole. Every possible combination was tested twice. After 72 hours, we observed the resulting necrotic tissue and calculated its volume. We assessed the determinants of %volume of necrotic tissue, defined as observed volume relative to the ideal volume of necrotic tissue.

resultsA transmural lesion was noted in 68 (94%) of 72 specimens. Using 4 applications, there was a strong linear relationship between voltage and %volume regardless of specimen thickness (R2 = 0.94, R2 = 0.96, R2 = 0.97, all P < .001) but not when using 2 applications (R2 = 0.37, R2 = 0.87, R2 = 0.69 for 10 mm, 20 mm, and 30 mm, respectively, all P < .05). The voltages at which 100% volume was observed using 4 applications-corresponding to the curve intersections-are 958 V, 928 V, and 1044 V for the 10 mm, 20 mm, and 30 mm specimens, respectively.

conclusionsThe epicardial PFA clamp reliably produced transmural lesions in a vegetal model of TS using 2 or 4 applications. With 4 applications, lesion volume demonstrated a predictable, linear relationship with increasing voltage, supporting the device's potential for controlled and consistent ablation.

Indexed as

Catheter AblationSolanumAnimalsEquipment DesignIrreversible Electroporation TherapyNecrosisTime Factorsatrial fibrillationCox-Maze procedureepicardial ablationpulsed field ablationsurgical ablation

Identifiers

PMID41978507
PMCPMC13131224

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