Evidence map›Paper›PMID 41978499›Full record

ArticleACS chemical neuroscience2026

Jessica M Lin, Benjamin Baah Konadu, Darci J Trader, Hai-Yan He

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jessica M LinBiology Department, Georgetown University, Washington, D.C. 20057, United States.
Benjamin Baah KonaduBiology Department, Georgetown University, Washington, D.C. 20057, United States.
Darci J TraderDepartment of Pharmaceutical Sciences, University of California, Irvine, California 92697, United States.ORCID 0000-0002-0607-1243
Hai-Yan HeBiology Department, Georgetown University, Washington, D.C. 20057, United States.ORCID 0000-0002-6692-6012

Funding

Nascent protein degradation-based fast homeostatic mechanism mediated by neuronal membrane proteasomesR01NS133441 · NINDS · GEORGETOWN UNIVERSITY · PI Haiyan He · 2023 to 2026
$1.5M
NINDS NIH HHS R01 NS133441
6 · The paper itself

Abstract

The proteasome is a major organelle responsible for protein degradation in neurons and has been implicated in the regulation of signal transduction and activity-dependent plasticity mechanisms that are essential for normal neuronal function. However, our understanding of the regulation of proteasome activity in the brain is limited by the currently available assays and tools. Here, we used a fluorogenic substrate-based probe, TAS1, to directly monitor proteasome activity in the brain of

Indexed as

NeuronsProteasome Endopeptidase ComplexSuperior ColliculiTime-Lapse ImagingAnimalsLarvaXenopus laevisProteasome Endopeptidase Complexin vivo time-lapse imagingneuronal activityoptic tectum: proteasome activitysubcellular compartmentsubstrate-based probe

Identifiers

PMID41978499
PMCPMC13154201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.