Evidence map›Paper›PMID 41978434›Full record

ArticleThe FEBS journal2026

Functional characterization of 42 CK2α de novo variants associated with Okur-Chung neurodevelopmental syndrome.

Alexander Gast, Christian Werner, Karsten Niefind, Joachim Jose

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The FEBS journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexander GastInstitute for Pharmaceutical and Medicinal Chemistry, University of Münster, Germany.ORCID https://orcid.org/0009-0001-1999-9155
Christian WernerDepartment of Chemistry and Biochemistry, Institute of Biochemistry, University of Cologne, Germany.
Karsten NiefindDepartment of Chemistry and Biochemistry, Institute of Biochemistry, University of Cologne, Germany.
Joachim JoseInstitute for Pharmaceutical and Medicinal Chemistry, University of Münster, Germany.ORCID https://orcid.org/0000-0002-0666-2676

Funding

Deutsche Forschungsgemeinschaft NI 643/11-1 Jo-183/10-1
6 · The paper itself

Abstract

In 2016, CSNK2A1, the gene which encodes the catalytic α-subunit of human protein kinase CK2 was linked to an autism spectrum disorder called Okur-Chung neurodevelopmental syndrome (OCNDS) for the first time. Human protein kinase CK2 is a heterotetrameric phosphotransferase with an α

Indexed as

Casein Kinase IINeurodevelopmental DisordersEnzyme StabilityHumansMutationCasein Kinase IICSNK2A1 protein, humanCK2CSNK2A1neurodevelopmental disordersOCNDSprotein kinase

Identifiers

PMID41978434
PMCPMC13628543

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.