Evidence map›Paper›PMID 41978406›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2026

[Endoscopic characteristics of primary gastric lymphoma and prediction of treatment response].

Jingyao Wei, Juxiang Ye, Meiling Zhou, Weiwei Fu, Xin Liu, Kangle Zhai, Yanyan Shi, Shigang Ding, Jing Zhang

Abstract readEnglish Abstract
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Jingyao WeiDepartment of Gastroenterology, Peking University Third Hospital, Beijing 100191, China.
Juxiang YeDepartment of Pathology, Peking University Third Hospital, Beijing 100191, China.
Meiling ZhouDepartment of Gastroenterology, Peking University Third Hospital, Beijing 100191, China.
Weiwei FuDepartment of Gastroenterology, Peking University Third Hospital, Beijing 100191, China.
Xin LiuDepartment of Gastroenterology, Peking University Third Hospital, Beijing 100191, China.
Kangle ZhaiDepartment of Gastroenterology, Peking University Third Hospital, Beijing 100191, China.
Yanyan ShiClinical Epidemiology Research Center, Peking University Third Hospital, Beijing 100191, China.
Shigang DingDepartment of Gastroenterology, Peking University Third Hospital, Beijing 100191, China.
Jing ZhangDepartment of Gastroenterology, Peking University Third Hospital, Beijing 100191, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePrimary gastric lymphoma (PGL) is a rare form of lymphoma that arises within the gastric mucosa-associated lymphoid tissue (MALT), often linked to

methodsA retrospective study was conducted involving 100 patients diagnosed with PGL at Peking University Third Hospital between January 2010 and January 2025. Patients were divided into two groups based on histopathological findings: indolent and aggressive lymphoma. The clinical and endoscopic characteristics of these two groups were compared. Survival analysis, including overall survival (OS) and progression-free survival (PFS), was performed using Kaplan-Meier curves and Log-rank tests. A subgroup of 25 patients with gastric MALT lymphoma and known HPE outcomes was selected for further analysis. Diagnostic biopsies were immunohistochemically stained with CD21 and BCL6 and graded from G0 to G4 based on follicular disruption. Logistic regression analysis was used to identify factors associated with HPE failure.

resultsAmong the 100 patients, the average age was 63.0 (55.8, 71.0) years, with 47 men and 53 women. Aggressive lymphoma showed a significantly higher incidence of B symptoms compared with indolent lymphoma (49.0%

conclusionPGL demonstrates considerable variability in its endoscopic presentation. Features, such as ulcerative/mixed morphology, friability, bleeding tendency, stenosis, and impaired peristalsis are indicative of more aggressive disease and correlate with poorer survival outcomes. The CD21/BCL6-based grading of lymphoid follicular disruption provides a valuable tool for identifying patients at high risk of HPE failure, supporting early intervention and risk stratification for gastric MALT lymphoma treatment.

Indexed as

Helicobacter InfectionsLymphoma, B-Cell, Marginal ZoneLymphoma, Non-HodgkinStomach NeoplasmsAgedFemaleHelicobacter pyloriHumansMaleMiddle AgedPrognosisProto-Oncogene Proteins c-bcl-6Receptors, Complement 3dRetrospective StudiesTreatment OutcomeBCL6 protein, humanProto-Oncogene Proteins c-bcl-6Receptors, Complement 3dEndoscopic featuresHelicobacter pylori eradication responseLymphoid follicular disruption gradingMucosa-associated lymphoid tissue (MALT) lymphomaPrimary gastric lymphoma

Identifiers

PMID41978406
PMCPMC13077308

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