ArticleAnnals of transplantation2026
Incidence, Clinical Features, and Risk Factors of Early Neurological Complications After Orthotopic Liver Transplantation: A Single-Center Experience.
Article in Annals of transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Despite improvements in technical and pharmacological expertise, orthotopic liver transplantation (OLT) still leads to potentially serious neurological complications (NCs) with very strong implications for graft survival, functional outcomes, and mortality. MATERIAL AND METHODS We conducted a retrospective study with the aim of defining the incidence, etiology, and clinical features of early post-OLT NCs, and we searched for preoperative, intraoperative and postoperative risk factors associated with their occurrence. RESULTS Among 376 patients who underwent OLT, 97 (25.8%) had at least 1 neurological manifestation and 24 (6.38%) had more than 1 neurological manifestation. Delirium/metabolic encephalopathy was the most frequent (14.1%), followed by seizures (3.7%) and clinical manifestations of neurotoxicity (3.7%), and then by osmotic demyelination syndrome and peripheral nervous system injury (2.9%). NCs were the cause of death in 9/97 patients, and 11 patients had severe sequelae. Having NCs was correlated with more severe liver disease, a history of chronic renal impairment, higher plasma sodium concentrations at postoperative day 2, higher perioperative delta sodium, and a higher probability of having postoperative acute renal impairment, postoperative infections, graft rejection, and more than 3 systemic complications. No preoperative neurological comorbidities were found to be risk factors for developing acute NCs early after OLT. Patients with NCs had worse outcomes: longer in-hospital length of stay, longer intensive care unit (ICU) stay, higher probability of ICU re-admission, higher probability of in-hospital death, and higher probability of needing rehabilitation after hospital discharge. CONCLUSIONS Understanding the pathophysiology of NCs after OLT may lead to the development of prevention strategies for often untreatable neurological diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.