Evidence map›Paper›PMID 41978019›Full record

ArticleSensors (Basel, Switzerland)2026

Seconds-Resolved Measurements of Vancomycin Transport from the Plasma to the Interstitial Fluid Highlight a Path Towards Real-Time Therapeutic Drug Monitoring.

Julian Gerson, Murat Kaan Erdal, Lisa C Fetter, Kaylyn K Leung, Nicole A Emmons, Joao Hespanha, Carl M Kirkpatrick, Kevin W Plaxco, Tod E Kippin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Julian GersonDepartment of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.ORCID 0000-0002-5922-4477
Murat Kaan ErdalDepartment of Electrical and Computer Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.ORCID 0000-0002-6073-2380
Lisa C FetterBiomolecular Sciences and Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.ORCID 0000-0002-1492-9449
Kaylyn K LeungDepartment of Molecular Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.ORCID 0000-0002-8966-801X
Nicole A EmmonsDepartment of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Joao HespanhaDepartment of Electrical and Computer Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.ORCID 0000-0003-2809-4718
Carl M KirkpatrickMonash Institute for Pharmaceutical Sciences, Monash University, Melbourne 3800, Australia.
Kevin W PlaxcoDepartment of Bioengineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Tod E KippinDepartment of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.

Funding

Bio-electrochemical detectors for in vivo continuous monitoringR01EB022015 · NIBIB · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI KIPPIN, TOD EDWARD, PLAXCO, KEVIN W · 2017 to 2025
$4.6M
NIH Common Fund R01EB022015
6 · The paper itself

Abstract

Continuous, in vivo drug and biomarker measurements could transform healthcare, enabling both the high-precision personalization of drug dosing and the real-time monitoring of health status. A practical realization of this vision, however, requires an improved understanding of the relationship between concentrations measured in the easily accessible dermal interstitial fluid (ISF) that correlate with the plasma concentrations that guide clinical decision making. As a preliminary step towards this goal, here we have used electrochemical, aptamer-based (EAB) sensors to perform seconds-resolved vancomycin measurements in the plasma and subcutaneous ISF of live rats. Concentrations of the antibiotic in the ISF vary rather little between different subcutaneous sites and, after the very rapid initial distribution phase is complete, they are well correlated with the plasma concentrations (mean R

Indexed as

Biosensing TechniquesDrug MonitoringExtracellular FluidPlasmaVancomycinAnimalsAnti-Bacterial AgentsRatsAnti-Bacterial AgentsVancomycinbiosensordermisperipheral tissuepharmacometrics

Identifiers

PMID41978019
PMCPMC13075304

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.