A Deep Learning-Guided Ensemble Empirical Mode Decomposition Method for Single-Channel Fetal Electrocardiogram Extraction.

The fetal electrocardiogram (FECG) is critical for assessing fetal cardiac electrophysiology and detecting fetal distress and arrhythmias. Single-channel abdominal electrocardiogram (AECG) enables home-based monitoring but faces challenges posed by weak fetal signals, maternal interference, and the lack of spatial information. Ensemble Empirical Mode Decomposition (EEMD) is suitable for nonstationary AECG signals but relies on accurate selection of intrinsic mode functions (IMFs). In this study, a deep learning-guided method was proposed: a one-dimensional convolutional neural network (1D CNN) scored and selected EEMD-derived IMFs, followed by maternal QRS template subtraction and secondary EEMD purification to achieve automatic FECG extraction. Leave-one-subject-out (LOSO) cross-validation was performed on 15 simulated cases and 5 ADFECGDB records, yielding a mean AUC of 0.9282 ± 0.0189 for the IMF classifier. On the independent DaISy and NIFEA arrhythmia datasets, the proposed CNN-2×EEMD method achieved correlation coefficients of 0.94-0.96, F1-scores of 0.8372-0.9565 for fetal R-peak detection, and SNR improvements of 13.39-15.88 dB. This method outperformed conventional automatic selection methods and matched the performance of manual selection. Ablation studies validated the optimal network design and IMF selection strategy, while complexity analysis (0.08 GFLOPs, 2.24 ms latency) confirmed its suitability for real-time wearable deployment.