Evidence map›Paper›PMID 41977506›Full record

ArticleInternational journal of molecular sciences2026

Evaluation of the Biological Standardization of Native Der p 1, Der p 2 and Der p 23 Proteins Isolated from Natural Allergen Source.

Ana I Tabar, David Rodríguez, Evelyn Gutierrez-Suazo, E Carolina Pinto, Cristina Pesántez-Méndez, Blanca E Garcia, Paloma Martín, Gema Garcia, Ricardo Palacios, Montserrat Martínez-Gomariz

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ana I TabarAllergology Service, Universitary Hospital of Navarra, 31008 Pamplona, Spain.ORCID 0000-0003-2586-086X
David RodríguezResearch and Development Department at Diater Laboratorios, 28919 Madrid, Spain.ORCID 0000-0001-5397-5766
Evelyn Gutierrez-SuazoAllergology Service, Universitary Hospital of Navarra, 31008 Pamplona, Spain.ORCID 0000-0003-0045-4566
E Carolina PintoAllergology Service, Universitary Hospital of Navarra, 31008 Pamplona, Spain.
Cristina Pesántez-MéndezAllergology Service, Universitary Hospital of Navarra, 31008 Pamplona, Spain.ORCID 0000-0001-8883-4445
Blanca E GarciaAllergology Service, Universitary Hospital of Navarra, 31008 Pamplona, Spain.ORCID 0000-0003-4463-4841
Paloma MartínResearch and Development Department at Diater Laboratorios, 28919 Madrid, Spain.
Gema GarciaResearch and Development Department at Diater Laboratorios, 28919 Madrid, Spain.
Ricardo PalaciosResearch and Development Department at Diater Laboratorios, 28919 Madrid, Spain.
Montserrat Martínez-GomarizResearch and Development Department at Diater Laboratorios, 28919 Madrid, Spain.ORCID 0000-0002-3082-3898

Funding

Centre for Industrial Technological Development IDI-20210095
6 · The paper itself

Abstract

House dust mite allergens Der p 1, Der p 2, and Der p 23 are recognized as major clinically relevant allergens worldwide; however, it is difficult to obtain these proteins in purified form from a natural source, which limits their use in molecular targeted immunotherapy and in vivo diagnosis. In this study, we developed and validated robust methodologies for the large-scale purification and individual characterization of native nDer p 1, nDer p 2, and nDer p 23 allergens from the natural sensitization source,

Indexed as

AllergensAntigens, DermatophagoidesArthropod ProteinsCysteine EndopeptidasesAnimalsDust Mite AllergyHumansSkin TestsAllergensAntigens, DermatophagoidesArthropod ProteinsCysteine EndopeptidasesDermatophagoides pteronyssinus antigen p 1Dermatophagoides pteronyssinus antigen p 2Der p 23 antigenHDMmolecular standardizationnative allergen purification

Identifiers

PMID41977506
PMCPMC13072800

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.