Evidence map›Paper›PMID 41977468›Full record

ReviewInternational journal of molecular sciences2026

The Molecular Signature of Early-Onset Colorectal Cancer Liver Metastases: Distinct Biology and Clinical Challenges.

Sophia Tsokkou, Ioannis Konstantinidis, Paraskevi Chatzikomnitsa, Menelaos Papakonstantinou, Areti Danai Gkaitatzi, Evdokia Toutziari, Dimitrios Alexandrou, Dimitrios Giakoustidis, Vasileios N Papadopoulos, Alexandros Giakoustidis

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sophia TsokkouFirst Department of Surgery, General Hospital Papageorgiou, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece.ORCID 0009-0000-1703-6980
Ioannis KonstantinidisLaboratory of Histology-Embryology, Department of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0009-0000-1632-821X
Paraskevi ChatzikomnitsaFirst Department of Surgery, General Hospital Papageorgiou, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece.
Menelaos PapakonstantinouFirst Department of Surgery, General Hospital Papageorgiou, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece.ORCID 0000-0001-5030-7009
Areti Danai GkaitatziFirst Department of Surgery, General Hospital Papageorgiou, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece.ORCID 0000-0002-1245-7804
Evdokia ToutziariFirst Department of Surgery, General Hospital Papageorgiou, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece.
Dimitrios AlexandrouFirst Department of Surgery, General Hospital Papageorgiou, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece.ORCID 0000-0003-2654-5845
Dimitrios GiakoustidisFirst Department of Surgery, General Hospital Papageorgiou, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece.ORCID 0000-0002-6023-4744
Vasileios N PapadopoulosFirst Department of Surgery, General Hospital Papageorgiou, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece.ORCID 0000-0002-1009-1685
Alexandros GiakoustidisFirst Department of Surgery, General Hospital Papageorgiou, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece.ORCID 0000-0002-3786-4609

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early-onset colorectal cancer (EOCRC), defined as diagnosis before the age of 50 years, is increasing globally and is frequently characterized by aggressive biology and a disproportionate burden of liver metastases. This review synthesizes emerging evidence on the distinct molecular, immunologic and clinical features that differentiate EOCRC liver metastases from those arising in older adults. Genomic studies revealed increased chromosomal instability, increased copy number variation burden and unique amplification patterns involving

Indexed as

Colorectal NeoplasmsLiver NeoplasmsAge of OnsetBiomarkers, TumorDNA Copy Number VariationsHumansMutationTumor MicroenvironmentBiomarkers, Tumorcopy number variationsearly-onset colorectal cancerferroptosisgenomic instabilityimmune microenvironmentimmunotherapy resistanceliver metastasesmolecular profilingPIK3CA-mutant CRCprecision oncology

Identifiers

PMID41977468
PMCPMC13073341

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.