Evidence map›Paper›PMID 41977465›Full record

ReviewInternational journal of molecular sciences2026

Unlocking the HOX: Homeobox Genes as Regulators of Hematopoietic Development.

Daniel A Moyer, Anika M Henning, Kay L Medina

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Daniel A MoyerMayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Anika M HenningDepartment of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
Kay L MedinaMayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-4188-8053

Funding

Regulation of the lymphoid cell fate by Hoxa9R01AG076163 · NIA · MAYO CLINIC ROCHESTER · PI MEDINA, KAY LYNN · 2022 to 2024
$954k
NIH HHS 1T32AI170478NIH HHS R01AG076163
6 · The paper itself

Abstract

Homeobox (HOX) transcription factors are encoded within highly organized loci expressed along an anterior-posterior axis through embryogenesis and in a pleiotropic manner in hematopoiesis. HOX expression has been exhaustively studied in the context of oncogenesis and malignancy, but the compensatory substitution of HOX paralogs makes mechanistic annotation in steady-state hematopoiesis challenging. Despite this, HOX genes reflect numerous non-redundant roles in healthy hematopoiesis including HSC self-renewal, development, lymphopoiesis, myelopoiesis, and erythropoiesis. Here, we review historical and current insights into HOX functions in steady-state hematopoiesis and highlight unexplored avenues in their biology that could further elucidate their significance to hematopoietic homeostasis.

Indexed as

Genes, HomeoboxHematopoiesisHomeodomain ProteinsAnimalsGene Expression Regulation, DevelopmentalHematopoietic Stem CellsHumansTranscription FactorsHomeodomain ProteinsTranscription FactorsB cellshematopoiesishematopoietic stem cellhomeoboxlymphoid developmenttranscription factor

Identifiers

PMID41977465
PMCPMC13072744

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.