Evidence map›Paper›PMID 41977433›Full record

ArticleInternational journal of molecular sciences2026

S-equol Modulates T3-Induced Transcription and Neurite Outgrowth in Neuronal Cells.

Yuki Fujiwara, Winda Ariyani, Ayane Ninomiya, Wataru Miyazaki, Ririka Ota, Izuki Amano, Noriyuki Koibuchi

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuki FujiwaraDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan.ORCID 0000-0001-7424-1016
Winda AriyaniDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan.ORCID 0000-0003-4813-6604
Ayane NinomiyaDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan.
Wataru MiyazakiDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan.
Ririka OtaSchool of Medicine, Gunma University, Maebashi 371-8511, Japan.
Izuki AmanoDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan.ORCID 0000-0002-5076-2041
Noriyuki KoibuchiDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan.ORCID 0000-0002-2247-9740

Funding

JSPS KAKENHI 18J23449JSPS KAKENHI 24K10021JSPS KAKENHI 25K20568
6 · The paper itself

Abstract

Thyroid hormones (THs) and estrogen (E2) play essential roles in neuronal differentiation and plasticity during brain development. S-equol, a plant-derived isoflavone metabolite, is a selective E2 receptor (ER) ligand that exhibits neurotrophic effects; however, its interaction with TH receptor (TR) signaling remains unclear. In this study, we investigated the effects of S-equol on TR

Indexed as

EquolNeuronal OutgrowthNeuronsTranscription, GeneticTriiodothyronineAnimalsCell Line, TumorMiceMolecular Docking SimulationNeuritesNeurodevelopmentRatsThyroid Hormone Receptors betaEquolThyroid Hormone Receptors betaTriiodothyronineneuronal morphogenesisS-equolthyroid hormone

Identifiers

PMID41977433
PMCPMC13073576

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.