Evidence map›Paper›PMID 41977423›Full record

ArticleInternational journal of molecular sciences2026

Pirfenidone Reduces Intracochlear Fibrosis Caused by Cochlear Implantation in a Guinea Pig Model.

Kady J Braack, Kelly L Short, Jorjina Plester, Tylah Miles, Lee Yong Lim, Marcus D Atlas, Jafri Kuthubutheen, Wilhelmina H A M Mulders, Cecilia M Prêle

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kady J BraackSchool of Human Sciences, University of Western Australia, Perth, WA 6009, Australia.
Kelly L ShortInstitute for Respiratory Health, University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0003-1242-5455
Jorjina PlesterInstitute for Respiratory Health, University of Western Australia, Perth, WA 6009, Australia.
Tylah MilesInstitute for Respiratory Health, University of Western Australia, Perth, WA 6009, Australia.
Lee Yong LimDepartment of Pharmacy, School of Health and Clinical Sciences, University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0002-7307-0742
Marcus D AtlasEar Science Institute Australia, Subiaco, WA 6008, Australia.ORCID 0000-0001-9830-259X
Jafri KuthubutheenMedical School, University of Western Australia, Perth, WA 6009, Australia.
Wilhelmina H A M MuldersSchool of Human Sciences, University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0001-8721-7357
Cecilia M PrêleInstitute for Respiratory Health, University of Western Australia, Perth, WA 6009, Australia.

Funding

National Health and Medical Research Council 2011143
6 · The paper itself

Abstract

While cochlear implants allow restoration of sound perception in individuals with severe to profound hearing loss, there remains significant variability in patient outcomes. A potential factor that may account for this unexplained variability is the formation of fibrosis within the cochlea after implantation. This study investigated the therapeutic potential of pirfenidone (PFD) in preventing cochlear implant-induced fibrosis and compared outcomes with dexamethasone (DEX) treated animals. The utility of PFD was determined in cultures of fibrocytes isolated from the inner ear of guinea pigs. Specifically, PFD-treatment significantly reduced p38 MAPK signalling, fibrocyte cell proliferation, migration and collagen III deposition in response to pro-fibrotic stimuli. In a guinea pig model, local hydrogel-mediated delivery of PFD to the round window at the time of implant surgery significantly reduced the amount of tissue reaction measured by micro-computed tomography at two months post-implantation (

Indexed as

CochleaCochlear ImplantationCochlear ImplantsFibrosisPyridonesAnimalsCell MovementCell ProliferationDexamethasoneDisease Models, AnimalGuinea Pigsp38 Mitogen-Activated Protein KinasesDexamethasonep38 Mitogen-Activated Protein KinasespirfenidonePyridonescochlear implantationfibrocytesfibrosisinner earpirfenidone

Identifiers

PMID41977423
PMCPMC13072998

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.