Evidence map›Paper›PMID 41977413›Full record

ArticleInternational journal of molecular sciences2026

MK2/p38/p53 Suppress Basal IL-1β and Non-Canonical NF-κB Signaling in Macrophages.

Sarah M Herr, Diana Stalkopf, Sofie Padaszus, Lukas A Herbst, Anneke Dörrie, Rainer Niedenthal, Natalia Ronkina, Tatiana Yakovleva, Alexey Kotlyarov, Matthias Gaestel

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sarah M HerrInstitute of Cell Biochemistry, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-8200-128X
Diana StalkopfInstitute of Cell Biochemistry, Hannover Medical School, 30625 Hannover, Germany.
Sofie PadaszusInstitute of Cell Biochemistry, Hannover Medical School, 30625 Hannover, Germany.
Lukas A HerbstInstitute of Cell Biochemistry, Hannover Medical School, 30625 Hannover, Germany.
Anneke DörrieInstitute of Cell Biochemistry, Hannover Medical School, 30625 Hannover, Germany.ORCID 0009-0004-8299-1860
Rainer NiedenthalInstitute of Cell Biochemistry, Hannover Medical School, 30625 Hannover, Germany.
Natalia RonkinaInstitute of Cell Biochemistry, Hannover Medical School, 30625 Hannover, Germany.
Tatiana YakovlevaInstitute of Cell Biochemistry, Hannover Medical School, 30625 Hannover, Germany.
Alexey KotlyarovInstitute of Cell Biochemistry, Hannover Medical School, 30625 Hannover, Germany.
Matthias GaestelInstitute of Cell Biochemistry, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-4944-4652

Funding

Hannover Medical School Hochschulinterne Leistungsförderung HiLF I
6 · The paper itself

Abstract

Interleukin (IL)-1β is a pro-inflammatory cytokine implicated in sterile inflammation and tumor development. Investigating the role of MAPKAP kinase 2 (MK2) in IL-1β processing, we found that

Indexed as

Interleukin-1betaIntracellular Signaling Peptides and ProteinsMacrophagesNF-kappa Bp38 Mitogen-Activated Protein KinasesProtein Serine-Threonine KinasesSignal TransductionTumor Suppressor Protein p53AnimalsHumansMAP-Kinase-Activated Kinase 2MiceMice, KnockoutInterleukin-1betaIntracellular Signaling Peptides and ProteinsMAP-Kinase-Activated Kinase 2NF-kappa Bp38 Mitogen-Activated Protein KinasesProtein Serine-Threonine KinasesTumor Suppressor Protein p53interleukin-1βMK2non-canonical NF-κB pathwayp38αp53

Identifiers

PMID41977413
PMCPMC13072840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.