Evidence map›Paper›PMID 41977410›Full record

ArticleInternational journal of molecular sciences2026

Characterization of Oncogenic and Immunogenic Profiling in Patients with Breast Cancer Tumors After Radiation Therapy.

Suryakant Niture, Carlos E Vargas, Saranya Chumsri, Jennifer M Kachergus, Sandeepkumar Sriramanujam, Dinesh Thotala, Jerry Jaboin, Danushka Seneviratne

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Suryakant NitureDepartment of Radiation Oncology, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0009-0004-9503-5659
Carlos E VargasDepartment of Radiation Oncology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA.
Saranya ChumsriDepartment of Radiation Oncology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA.ORCID 0000-0001-7117-1446
Jennifer M KachergusDepartment of Radiation Oncology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA.
Sandeepkumar SriramanujamDepartment of Radiation Oncology, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA.
Dinesh ThotalaDepartment of Radiation Oncology, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0000-0001-5355-6406
Jerry JaboinDepartment of Radiation Oncology, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA.
Danushka SeneviratneDepartment of Radiation Oncology, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA.

Funding

investigator-initiated trials grant to Danushka Seneviratne MDSCC309NIH- National Cancer Institute P30 CA225520-CCSG 20009931
6 · The paper itself

Abstract

Biological heterogeneity among different breast cancer (BC) subtypes results in markedly varying clinical outcomes. Identification and analysis of key gene biomarkers that are differentially regulated during radiation therapy (RT) may pose multiple clinical challenges for BC treatment. The purpose of the study is to identify and analyze the expression of key gene biomarkers and their networks that are differentially regulated after hypofractionated RT. Patients with BC (cT0-T2, N0, M0) were treated with hypofractionated whole breast RT 25 Gy in five fractions, 4 to 8 weeks before breast conservation surgery (BCS). Biopsy (pre-RT;

Indexed as

Breast NeoplasmsBiomarkers, TumorFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansMiddle AgedTranscriptomeTumor MicroenvironmentBiomarkers, Tumorbreast cancergene biomarkerimmune cellsoncogeneresidual cancer burden

Identifiers

PMID41977410
PMCPMC13073414

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.