ArticleInternational journal of molecular sciences2026
Evaluation of +49 A>G (rs231775) Variant in CTLA4 Gene and SCTLA-4 Serum Levels in Plaque Psoriasis in a Mestizo Mexican Population.
María Guadalupe Cortés-Ruiz, Katia Alejandra Wheber-Hidalgo, Brenda Fernanda Hernández-Nicols, Fernando Gabriel Buenrostro-Camacho, Jorge Hernández-Bello, Omar Graciano-Machuca, Anabell Alvarado-Navarro
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In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
7 authors.
María Guadalupe Cortés-RuizCentro de Investigación en Inmunología y Dermatología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Colonia Independencia, Guadalajara 44340, Jalisco, Mexico.
Katia Alejandra Wheber-HidalgoCentro de Investigación en Inmunología y Dermatología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Colonia Independencia, Guadalajara 44340, Jalisco, Mexico.
Brenda Fernanda Hernández-NicolsCentro de Investigación en Inmunología y Dermatología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Colonia Independencia, Guadalajara 44340, Jalisco, Mexico.ORCID 0009-0000-6469-3254 Fernando Gabriel Buenrostro-CamachoCentro de Investigación en Inmunología y Dermatología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Colonia Independencia, Guadalajara 44340, Jalisco, Mexico.
Jorge Hernández-BelloInstituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Colonia Independencia, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0001-8004-1811 Omar Graciano-MachucaCentro de Investigación en Procesamiento Digital de Señales, Centro Universitario de los Valles, Universidad de Guadalajara, Carretera a Guadalajara, Supermanzana El Km 45.5, Caimanero 46708, Jalisco, Mexico.
Anabell Alvarado-NavarroCentro de Investigación en Inmunología y Dermatología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Colonia Independencia, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0002-5719-1712 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Plaque psoriasis (PP) is a chronic immune-mediated skin disorder characterized by T-cell dysregulation and an imbalance between regulatory T cells (Treg) and T helper 17 (Th17) cells. Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), a key inhibitory checkpoint molecule expressed on Treg cells, and its soluble isoform (sCTLA-4) are critical regulators of peripheral immune tolerance and may contribute to PP pathogenesis. This case-control study evaluated the association between the +49 A>G variant of the
Indexed as
CTLA-4 AntigenPolymorphism, Single NucleotidePsoriasisAdultAllelesCase-Control StudiesFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansMaleMexicoMiddle AgedCTLA-4 AntigenCTLA4 protein, humanCTLA4 variantgenetic susceptibilityimmune checkpointplaque psoriasisrs231775soluble CTLA-4
Identifiers
PMID41977385
PMCPMC13073593
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