SynthesisInternational journal of molecular sciences2026
Advances in Male Reproductive Toxicology of Nanoplastics: Potential Risks to Human Reproduction-A Systematic Review.
Synthesis in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Lactational exposure to polystyrene nanoplastics induces oxidative stress, testicular histological alterations, and impaired sperm quality in rat offspring.Histochemistry and cell biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Microplastics and nanoplastics (MPs/NPs) have emerged as pervasive and persistent environmental contaminants, prompting significant concerns about their potential risks to human health. This review provides a comprehensive synthesis of the current state of knowledge on the reproductive toxicity induced by MPs/NPs, with a particular focus on nanoplastics (NPs, <100 nm) due to their enhanced ability to cross biological barriers and induce cellular damage. Following a systematic literature search, we detail the multiple exposure pathways-including ingestion, inhalation, and dermal contact-through which MPs/NPs enter the human body and are disseminated to reproductive tissues. The core of this review elucidates the fundamental mechanisms underlying MPs/NPs-induced reproductive damage. Compelling evidence from in vitro, animal, and initial human studies demonstrates that MP/NP exposure can lead to diminished sperm quality and motility, testicular histological disruption, impaired ovarian folliculogenesis, granulosa cell apoptosis, and dysregulation of key reproductive hormones. We further summarize potential therapeutic interventions, such as antioxidants and traditional Chinese medicine compounds, and discuss key preventive and regulatory strategies. Despite the advancing evidence, critical challenges remain, including quantifying actual human exposure levels, understanding the effects of chronic, low-dose exposure, and elucidating the combined toxicity of MPs/NPs with other environmental pollutants. This comprehensive analysis underscores the urgent need for further mechanistic research, robust epidemiological studies, and the formulation of evidence-based public health policies to mitigate exposure and safeguard global reproductive health.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.