Evidence map›Paper›PMID 41977374›Full record

ArticleInternational journal of molecular sciences2026

HIV Promoters Isolated from Brain and Peripheral Tissue of Virally Suppressed PWH Are Phylogenetically and Functionally Similar.

Janna Jamal Eddine, Emily K Chalmers, Jingling Zhou, Sarah J Byrnes, Trisha A Jenkins, Narin Osman, Anna C Hearps, Michael Roche, Thomas A Angelovich, Melissa J Churchill

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Janna Jamal EddineATRACT Leading Research Centre, School of Health and Biomedical Sciences, RMIT University, Melbourne 3000, Australia.
Emily K ChalmersATRACT Leading Research Centre, School of Health and Biomedical Sciences, RMIT University, Melbourne 3000, Australia.ORCID 0009-0002-0736-1792
Jingling ZhouATRACT Leading Research Centre, School of Health and Biomedical Sciences, RMIT University, Melbourne 3000, Australia.
Sarah J ByrnesATRACT Leading Research Centre, School of Health and Biomedical Sciences, RMIT University, Melbourne 3000, Australia.
Trisha A JenkinsATRACT Leading Research Centre, School of Health and Biomedical Sciences, RMIT University, Melbourne 3000, Australia.ORCID 0000-0003-0137-6643
Narin OsmanATRACT Leading Research Centre, School of Health and Biomedical Sciences, RMIT University, Melbourne 3000, Australia.ORCID 0000-0002-6738-6513
Anna C HearpsLife Sciences Discipline, Burnet Institute, Melbourne 3004, Australia.
Michael RocheATRACT Leading Research Centre, School of Health and Biomedical Sciences, RMIT University, Melbourne 3000, Australia.
Thomas A AngelovichATRACT Leading Research Centre, School of Health and Biomedical Sciences, RMIT University, Melbourne 3000, Australia.ORCID 0000-0003-2069-0451
Melissa J ChurchillATRACT Leading Research Centre, School of Health and Biomedical Sciences, RMIT University, Melbourne 3000, Australia.

Funding

Characterization of the intact and defective HIV reservoirs in myeloid cells in the brainR21DA055489 · NIDA · ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY · PI ANGELOVICH, THOMAS A, CHURCHILL, MELISSA · 2021 to 2022
$272k
National Health and Medical Research Council GNT1183032National Health and Medical Research Council GNT2020633NIDA NIH HHS R21DA055489
6 · The paper itself

Abstract

Despite viral suppression with antiretroviral therapy (ART), reservoirs of Human Immunodeficiency Virus (HIV) persist in anatomical compartments throughout the body, including the brain. We have previously demonstrated that the HIV long terminal repeats (LTRs) isolated from the brains of non-virally suppressed people with HIV (PWH) are phylogenetically and functionally distinct from those isolated from matched peripheral tissue. While intact, transcriptionally competent HIV genomes persist within the brains of virally suppressed PWH, whether HIV LTRs are intact, functional, and compartmentalized relative to the periphery, as in non-virally suppressed PWH, remains unclear. HIV LTRs were extracted from frontal cortex post-mortem brain and matched peripheral tissues of virally suppressed PWH (

Indexed as

BrainHIV-1HIV InfectionsHIV Long Terminal RepeatPromoter Regions, GeneticHumansPhylogenybraincompartmentalizationHIVLTRreservoirsequencingtranscription factor binding sites

Identifiers

PMID41977374
PMCPMC13073275

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.