Evidence map›Paper›PMID 41977359›Full record

ArticleInternational journal of molecular sciences2026

Anti-Inflammatory Effects of Pingyin Rose Essential Oil in LPS-Induced HaCaT Cells: An in Vitro and in Silico Study.

Jingyi Song, Rifat Nowshin Raka, Zhongwei Zhang, Junsong Xiao, Mingquan Huang, Hua Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jingyi SongBeijing Key Laboratory of Plant Resource Research and Development, Beijing Technology and Business University, Beijing 100048, China.
Rifat Nowshin RakaBeijing Key Laboratory of Plant Resource Research and Development, Beijing Technology and Business University, Beijing 100048, China.ORCID 0000-0002-3337-5605
Zhongwei ZhangKey Laboratory of Brewing Molecular Engineering of China Light Industry, Beijing Technology and Business University, Beijing 100048, China.
Junsong XiaoKey Laboratory of Brewing Molecular Engineering of China Light Industry, Beijing Technology and Business University, Beijing 100048, China.ORCID 0000-0001-6778-8187
Mingquan HuangKey Laboratory of Brewing Molecular Engineering of China Light Industry, Beijing Technology and Business University, Beijing 100048, China.ORCID 0000-0003-1344-8456
Hua WuKey Laboratory of Brewing Molecular Engineering of China Light Industry, Beijing Technology and Business University, Beijing 100048, China.ORCID 0000-0002-6916-1596

Funding

This research was supported Beijing municipal education commission general project KM202010011010
6 · The paper itself

Abstract

Pingyin rose essential oil (PREO) is extracted from fresh petals exclusively cultivated in Shandong Province. This PREO has been used in traditional Chinese medicine (TCM) for decades to treat skin issues like excessive oxidative stress and inflammation. The purpose of this study was to assess the impact of PREO on the inflammatory pathway in HaCaT cells produced by LPS. In vitro methods were used to ascertain the expression of inflammatory proteins, and network pharmacological analysis was employed to predict the signaling pathway. According to our findings, PREO significantly reduced LPS-induced oxidative stress, decreasing nitric oxide (NO) and reactive oxygen species (ROS) production by 42% and 38%, respectively, and malondialdehyde (MDA) levels by 35%, while enhancing superoxide dismutase (SOD) activity by 28% (

Indexed as

Anti-Inflammatory AgentsLipopolysaccharidesOils, VolatileRosaCytokinesHaCaT CellsHumansInflammationKeratinocytesMolecular Docking SimulationNF-kappa BNitric OxideOxidative StressReactive Oxygen SpeciesSignal TransductionToll-Like Receptor 4Anti-Inflammatory AgentsCytokinesLipopolysaccharidesNF-kappa BNitric OxideOils, VolatileReactive Oxygen SpeciesToll-Like Receptor 4network pharmacologyoxidative stressskin inflammationTLR4-NF-κB pathway

Identifiers

PMID41977359
PMCPMC13072962

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.