Evidence map›Paper›PMID 41977339›Full record

ArticleInternational journal of molecular sciences2026

Severe Factor XII Deficiency in a Patient with Spontaneous Coronary Artery Dissection.

Artemis Zormpa, Efrosyni G Nomikou, Dimitrios Kalantzis, Georgios Apergis, Virginia Zouganeli, Efthymia G Pavlou, Despina Mavridou, Georgios Katsadiotis, Loukianos S Rallidis, Styliani Kokoris

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Artemis ZormpaLaboratory of Hematology and Blood Bank Unit, "Attikon" University General Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.ORCID 0000-0002-8303-6513
Efrosyni G NomikouBlood Bank and Hemophilia Unit, Hippokration Hospital, 115 27 Athens, Greece.
Dimitrios KalantzisLaboratory of Hematology and Blood Bank Unit, "Attikon" University General Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.
Georgios ApergisDepartment of Molecular Diagnosis, "Hippokration" General Hospital, 115 27 Athens, Greece.
Virginia Zouganeli2nd Department of Cardiology, "Attikon" University General Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.
Efthymia G PavlouBlood Bank and Hemophilia Unit, Hippokration Hospital, 115 27 Athens, Greece.ORCID 0000-0002-5855-0895
Despina MavridouLaboratory of Hematology and Blood Bank Unit, "Attikon" University General Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.
Georgios KatsadiotisLaboratory of Hematology and Blood Bank Unit, "Attikon" University General Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.
Loukianos S Rallidis2nd Department of Cardiology, "Attikon" University General Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.ORCID 0000-0002-7349-0309
Styliani KokorisLaboratory of Hematology and Blood Bank Unit, "Attikon" University General Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Factor XII (FXII) deficiency is a coagulation factor disorder inherited in an autosomal recessive manner that causes prolonged activated partial thromboplastin time (aPTT). Although it is clinically benign without additional bleeding risk, it has been associated with paradoxical thrombosis. We report the case of a 38-year-old woman who presented with cardiac arrest secondary to spontaneous coronary artery dissection (SCAD) in the absence of identifiable risk factors. Laboratory investigations revealed an isolated prolonged aPTT, which was corrected with mixing studies, and a severe FXII deficiency with activity levels < 1%. Molecular analysis identified two homozygous

Indexed as

Coronary Vessel AnomaliesFactor XIIFactor XII DeficiencyVascular DiseasesAdultDissection, Blood VesselFemaleHumansPartial Thromboplastin TimeFactor XIIaPTTbleedingcardiac arrestcoagulationF12factor 12factor XIIfibrinolysisFXIIgenehaematologyhematologyhomozygous variantpoint mutationSCADspontaneous artery dissectionthrombosisvascular injury

Identifiers

PMID41977339
PMCPMC13073069

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.