Clinical Value of Neutrophil Gelatinase-Associated Lipocalin as a Non-Invasive Biomarker for Intestinal Ulcer in Behçet's Syndrome: A Pilot Study.

Jing-Fen Ye, Yi-Xuan Zhang, Dan Hu, Jian-Fei Cai, Yu-Xin Liu, Li-Yang Zhang, Jun Zou, Jian-Long Guan

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Jing-Fen YeDepartment of Rheumatology and Immunology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.

Yi-Xuan ZhangDepartment of Rheumatology and Immunology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.

Dan HuDepartment of Rheumatology and Immunology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.

Jian-Fei CaiDepartment of Rheumatology and Immunology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.

Yu-Xin LiuDepartment of Rheumatology and Immunology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.

Li-Yang ZhangDepartment of Rheumatology and Immunology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.

Jun ZouDepartment of Rheumatology and Immunology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.

Jian-Long GuanDepartment of Rheumatology and Immunology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.ORCID 0000-0002-6481-480X

Funding

This research was supported by the clinical study on the value of fecal neutrophil gelatinase-associated lipocalin in the early diagnosis of intestinal Behçe't disease 20234Y0110

6 · The paper itself

Abstract

Intestinal Behçet's syndrome (BS) is a severe phenotype associated with high morbidity and mortality. Early identification of intestinal involvement in BS remains clinically challenging due to the lack of reliable biomarkers. Neutrophil gelatinase-associated lipocalin (NGAL) is abundantly secreted during intestinal inflammation and has been recognized as a promising inflammatory biomarker. This study was designed to investigate the clinical value of NGAL for predicting intestinal involvement in BS patients. BS patients who underwent colonoscopy for suspected intestinal lesions were enrolled and classified into intestinal BS and non-intestinal BS groups. Immunohistochemistry was performed to compare colonic mucosal NGAL expression among intestinal BS, non-intestinal BS, inflammatory bowel disease (IBD) patients, and healthy controls. Serum and fecal NGAL levels were also measured in intestinal BS, non-intestinal BS, and healthy controls. Intestinal mucosal NGAL expression was significantly elevated in both intestinal BS and IBD patients, with no significant difference between the two groups. Serum and fecal NGAL levels were both higher in intestinal BS patients than in healthy controls. Notably, only fecal NGAL was significantly increased in intestinal BS compared to non-intestinal BS (

Indexed as

Behcet SyndromeIntestinal DiseasesLipocalin-2UlcerAdultBiomarkersCase-Control StudiesFecesFemaleHumansIntestinal MucosaMaleMiddle AgedPilot ProjectsBiomarkersLCN2 protein, humanLipocalin-2biomarkerintestinal Behçet’s syndromeneutrophil gelatinase-associated lipocalin2

Identifiers

PMID41977338

DOI10.3390/ijms27073152

PMCPMC13073483

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