Evidence map›Paper›PMID 41977336›Full record

ArticleInternational journal of molecular sciences2026

High-Dose Voclosporin Protects Against Acute Kidney Injury via Regnase-2-Mediated NGAL MRNA Decay.

Kazuhiro Hasegawa, Yusuke Sakamaki, Masanori Tamaki, Sumiyo Yamaguchi, Shinji Miyakami, Chihiro Okinari, Miho Tada, Makoto Otsuka, Masanori Minato, Shu Wakino

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kazuhiro HasegawaDepartment of Nephrology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan.ORCID 0000-0003-3113-4522
Yusuke SakamakiDepartment of Nephrology and Endocrinology, National Defense Medical College, Tokorozawa 359-8513, Japan.
Masanori TamakiDepartment of Nephrology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan.ORCID 0000-0002-0488-0098
Sumiyo YamaguchiDepartment of Nephrology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan.
Shinji MiyakamiDepartment of Nephrology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan.
Chihiro OkinariDepartment of Nephrology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan.
Miho TadaDepartment of Nephrology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan.
Makoto OtsukaDepartment of Nephrology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan.
Masanori MinatoDepartment of Nephrology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan.
Shu WakinoDepartment of Nephrology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute kidney injury (AKI) is a major complication of lupus nephritis and kidney transplantation, inevitably causing ischemia-reperfusion (I/R) injury. We previously confirmed that high-dose voclosporin induces drug nephropathy through aberrant peroxisome accumulation. The latter induces increased renal indole-3-aceticT acid (IAA) production due to the decreased expression of the IAA-degrading enzyme indolethylamine N-methyltransferase (INMT). Conversely,

Indexed as

Acute Kidney InjuryCyclosporineLipocalin-2RNA StabilityAnimalsHepatitis A Virus Cellular Receptor 1MaleMiceReperfusion InjuryRibonucleasesCyclosporineHavcr1 protein, mouseHepatitis A Virus Cellular Receptor 1Lcn2 protein, mouseLipocalin-2RibonucleasesZc3h12a protein, mouseInmtRegnase-2voclosporin

Identifiers

PMID41977336
PMCPMC13072766

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.