Evidence map›Paper›PMID 41977330›Full record

ArticleInternational journal of molecular sciences2026

Binding Affinity and Interaction Profiles of Erinacines and Erinacerins with iNOS and NF-

April Michelle Hernandez-Munguia, Andrés Reyes-Chaparro, Tomas Alejandro Fregoso-Aguilar, Aldo Yair Tenorio-Barajas, Jorge Alberto Mendoza-Pérez, Ricardo Aguilar-Garay, Dulce E Nicolás-Álvarez

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

April Michelle Hernandez-MunguiaLaboratorio de Hormonas y Conducta, Departamento de Fisiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 07700, Mexico.ORCID 0009-0004-1755-4859
Andrés Reyes-ChaparroDepartamento de Morfología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 11340, Mexico.ORCID 0000-0002-6677-0740
Tomas Alejandro Fregoso-AguilarLaboratorio de Hormonas y Conducta, Departamento de Fisiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 07700, Mexico.ORCID 0000-0003-0824-1792
Aldo Yair Tenorio-BarajasLaboratorio de Nanobiotecnologia, Facultad de Ciencias Físico Matemáticas, Benemerita Universidad de Puebla, Av. San Cladio y 18 Sur, Col. San Manuel, Edif. FM6-108, Ciudad Universitaria, Puebla 72570, Mexico.ORCID 0000-0001-7256-5199
Jorge Alberto Mendoza-PérezLaboratorio de Tecnologías Limpias, Desarrollo de Procesos Ambientales e Ingeniería Verde, Departamento de Ingeniería en Sistemas Ambientales, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 07700, Mexico.ORCID 0000-0002-8651-3506
Ricardo Aguilar-GarayLaboratorio de Hormonas y Conducta, Departamento de Fisiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 07700, Mexico.ORCID 0000-0002-3566-1330
Dulce E Nicolás-ÁlvarezLaboratorio de Hormonas y Conducta, Departamento de Fisiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 07700, Mexico.ORCID 0000-0002-1717-9081

Funding

Instituto Politécnico Nacional (IPN), Secretaría de Investigación y Posgrado (SIP) 20251006, 20260719, 20251240, 20251004, and 20260252
6 · The paper itself

Abstract

Chronic neuroinflammation driven by microglial activation is a pathological hallmark of neurodegenerative diseases, and the NF-κB/iNOS signaling axis plays a central role in propagating this damage. NF-κB-mediated iNOS transcription generates excessive nitric oxide, causing oxidative neuronal injury. The medicinal mushroom

Indexed as

DiterpenesNF-kappa BNitric Oxide Synthase Type IIHericiumHumansMolecular Docking SimulationMolecular Dynamics SimulationProtein BindingcyathaneDiterpenesNF-kappa BNitric Oxide Synthase Type IIbinding affinityerinacerinserinacinesHericium erinaceusiNOSMM-PBSAmolecular dockingmolecular dynamicsneuroinflammationNF-κB

Identifiers

PMID41977330
PMCPMC13073928

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.