Evidence map›Paper›PMID 41977312›Full record

ArticleInternational journal of molecular sciences2026

Integrative In Silico Analysis of miRNA-mRNA Regulatory Networks in the Prefrontal Cortex of Individuals with Psychiatric Disorders Who Died by Suicide.

José Luis Cortéz-Sánchez, Hernán Mauricio Rivera-Escobar, Esther Natalia Muñoz Roa, Carlos Andrés Zabala-Bello, Gilberto Pérez-Sánchez, José Miguel Chin Chan, Monserrat Bautista-Ortiz, Karla María López-Martínez, Federico Osorio-Antonio, José Luis Gálvez-Romero and 4 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

José Luis Cortéz-SánchezEnvironmental Epigenetics and Mental Health Laboratory, Faculty of Chemical Biological Sciences, Autonomous University of Campeche, Campeche 24085, Mexico.
Hernán Mauricio Rivera-EscobarResearch Group on Biosciences, Pedagogy, and Socio-Environmental Sciences BIOPESA, University of Tolima, Ibagué 730006, Colombia.ORCID 0000-0002-8901-4059
Esther Natalia Muñoz RoaPhD Program in Biological Sciences, Pontificia Universidad Javeriana, Bogotá 110211, Colombia.ORCID 0000-0002-1368-7732
Carlos Andrés Zabala-BelloAnimal Science and Veterinary Medicine Faculty, Universidad Nacional de Colombia, Bogotá 15372, Colombia.ORCID 0000-0003-2793-6223
Gilberto Pérez-SánchezPsychoimmunology Laboratory, Neuroscience Department, Ramón de la Fuente Muñiz National Institute of Psychiatry, Mexico City 14370, Mexico.ORCID 0000-0003-3878-0631
José Miguel Chin ChanEnvironmental Epigenetics and Mental Health Laboratory, Faculty of Chemical Biological Sciences, Autonomous University of Campeche, Campeche 24085, Mexico.
Monserrat Bautista-OrtizCentro Tlaxcala de Biología de la Conducta, Universidad Autónoma de Tlaxcala, Tlaxcala 90062, Mexico.
Karla María López-MartínezIndependent Researcher, Puebla 72410, Mexico.ORCID 0000-0002-9770-6258
Federico Osorio-AntonioHospital Infantil de Tlaxcala (HIT), Tlaxcala 90606, Mexico.ORCID 0000-0002-3841-2663
José Luis Gálvez-RomeroHospital Regional del ISSSTE, Puebla 72570, Mexico.
Alan Carrasco CarballoSECIHTI, LESQO Adscrito a la Benemérita Universidad Autónoma de Puebla, Puebla 72590, Mexico.ORCID 0000-0003-1065-4211
Virginia Sedeño-MongeDecanato de Ciencias Médicas, Universidad Popular Autónoma del Estado de Puebla (UPAEP)-SECIHTI-Puebla, Puebla 72410, Mexico.
Francisco CastelánCentro Tlaxcala de Biología de la Conducta, Universidad Autónoma de Tlaxcala, Tlaxcala 90062, Mexico.ORCID 0000-0002-9835-3335
Elizabeth Bautista-RodríguezMultidisciplinary Laboratory in Biomedicine, Biotechnology and Integrative Bioinformatics Applied to Health (LAMB3IS), Faculty of Health Sciences, Autonomous University of Tlaxcala (UATx), Zacatelco 90750, Mexico.

Funding

International Brain Research Organization Early Career AwardsSECIHTI CBF-2025_I-3072SECIHTI/CONAHCYT FORDECYT-PRONACES/3203
6 · The paper itself

Abstract

To explore the regulatory aspects of mRNAs and miRNAs in suicide, we integrated transcriptomic data from GEO datasets. The analysis of mRNA expression in the prefrontal cortex of suicide victims with major depressive disorder revealed a differential profile with 27 downregulated mRNAs, including

Indexed as

Gene Regulatory NetworksMajor Depressive DisorderMental DisordersMicroRNAsPrefrontal CortexRNA, MessengerSuicideAntigens, DifferentiationComputational BiologyGADD45 ProteinsGene Expression ProfilingGene Expression RegulationHumansAntigens, DifferentiationGADD45B protein, humanGADD45 ProteinsMicroRNAsRNA, MessengerbiomarkersmiRNAsmRNAregulatory networksuicide

Identifiers

PMID41977312
PMCPMC13073591

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.