Evidence map›Paper›PMID 41977299›Full record

ArticleInternational journal of molecular sciences2026

A Pilot Study on Multigenic Thrombophilic Risk in Recurrent Pregnancy Loss: Interactions Between MTHFR Polymorphisms and Classical Thrombophilia-Associated SNPs.

Oana-Viola Badulescu, Monica Hancianu, Cornelia Mircea, Andrei Bojan, Dragos-Florin Tesoi, Maria Cristina Vladeanu, Manuela Ciocoiu, Otilia-Elena Frasinariu, Carmen Elena Plesoianu, Dan Iliescu-Halitchi and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Oana-Viola BadulescuDepartment of Pathophysiology, Morpho-Functional Sciences (II), Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania.ORCID 0000-0001-7050-8430
Monica HancianuFaculty of Pharmacy, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania.
Cornelia MirceaFaculty of Pharmacy, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania.ORCID 0000-0002-1981-8246
Andrei BojanDepartment of Surgical Sciences, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania.
Dragos-Florin TesoiDepartment of Pathophysiology, Morpho-Functional Sciences (II), Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania.
Maria Cristina VladeanuDepartment of Pathophysiology, Morpho-Functional Sciences (II), Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania.
Manuela CiocoiuDepartment of Pathophysiology, Morpho-Functional Sciences (II), Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania.ORCID 0000-0002-9240-2175
Otilia-Elena FrasinariuEmergency Clinical Hospital for Children "Sfanta Maria" Iasi, 700309 Iasi, Romania.ORCID 0000-0002-5836-1517
Carmen Elena PlesoianuDepartment of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania.ORCID 0000-0002-5448-7761
Dan Iliescu-HalitchiDepartment of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania.
Iris Bararu BojanDepartment of Pathophysiology, Morpho-Functional Sciences (II), Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Iasi, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrent spontaneous miscarriages represent a significant reproductive challenge, often associated with inherited thrombophilia. Among the genetic factors involved, methylenetetrahydrofolate reductase (

Indexed as

Abortion, HabitualMethylenetetrahydrofolate Reductase (NADPH2)Polymorphism, Single NucleotideThrombophiliaAdultFactor VFemaleGenetic Predisposition to DiseaseHumansPilot ProjectsPregnancyProthrombinRetrospective StudiesRisk FactorsFactor Vfactor V LeidenMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanProthrombinFactor V Leiden mutationinherited thrombophiliamethylenetetrahydrofolate reductase gene polymorphismsmultigenic riskrecurrent pregnancy loss

Identifiers

PMID41977299
PMCPMC13073514

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.