Evidence map›Paper›PMID 41977297›Full record

ArticleInternational journal of molecular sciences2026

Structure-Based Design of New Series of Sulfonates with Potent and Specific BChE Inhibition and Anti-Inflammatory Effects.

Siva Hariprasad Kurma, Camila Adarvez-Feresin, Oscar Parravicini, Adriana Garro, Sarka Stepankova, Jan Hosek, Karel Pauk, Jovana Lisicic, Josef Jampilek, Ricardo Daniel Enriz and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Siva Hariprasad KurmaInstitute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic.ORCID 0000-0002-6597-192X
Camila Adarvez-FeresinInstituto Multidisciplinario de Investigaciones Biológicas (IMIBIO-SL), Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco 915, San Luis 5700, Argentina.ORCID 0000-0003-4308-9706
Oscar ParraviciniInstituto Multidisciplinario de Investigaciones Biológicas (IMIBIO-SL), Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco 915, San Luis 5700, Argentina.
Adriana GarroInstituto Multidisciplinario de Investigaciones Biológicas (IMIBIO-SL), Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco 915, San Luis 5700, Argentina.
Sarka StepankovaDepartment of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic.ORCID 0000-0002-1969-5258
Jan HosekDepartment of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 296/70, 621 00 Brno, Czech Republic.ORCID 0000-0003-0975-1671
Karel PaukInstitute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic.
Jovana LisicicDepartment of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 296/70, 621 00 Brno, Czech Republic.
Josef JampilekDepartment of Chemical Biology, Faculty of Science, Palacky University Olomouc, Slechtitelu 27, 779 00 Olomouc, Czech Republic.ORCID 0000-0003-2003-9052
Ricardo Daniel EnrizInstituto Multidisciplinario de Investigaciones Biológicas (IMIBIO-SL), Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco 915, San Luis 5700, Argentina.
Ales ImramovskyInstitute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic.ORCID 0000-0001-9476-9627

Funding

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)Ministry of Agriculture DKRVO RO0523National University of San LuisSlovak Research and Development Agency APVV-24-0341
6 · The paper itself

Abstract

In the present work, a novel series of eleven sulfonate derivatives with potent inhibitory activity against butyrylcholinesterase (BChE) is reported. Of these, compounds 2-[(

Indexed as

Anti-Inflammatory AgentsButyrylcholinesteraseCholinesterase InhibitorsDrug DesignSulfonic AcidsAnimalsHumansMolecular Docking SimulationMolecular Dynamics SimulationStructure-Activity RelationshipAnti-Inflammatory AgentsButyrylcholinesteraseCholinesterase InhibitorsSulfonic AcidsAlzheimer’s diseaseanti-inflammatory activityBChE activitymolecular modelingQTAIM calculationssulfonate derivatives

Identifiers

PMID41977297
PMCPMC13072879

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.