Evidence map›Paper›PMID 41977284›Full record

ArticleInternational journal of molecular sciences2026

CLARIX FLO Inhibits DRG Adhesion-Induced Neuropathic Pain Through the CD44-TRPV1 Signaling Pathway.

Chia-Chi Kung, Shih-Ping Dai, Chao-Chiang Tu, Tsung-An Tsai, Po-Heng Chen, Chao-Hsien Sung, Chun-Hsien Fu, Jen-Hao Liu, Chih-Li Chen

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Chia-Chi KungSchool of Medicine, College of Medicine, Fu Jen Catholic University, No. 510 Zhongzheng Rd., Xinzhuang Dist., New Taipei 24205, Taiwan.
Shih-Ping DaiDepartment of Anesthesiology, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei 24352, Taiwan.
Chao-Chiang TuSchool of Medicine, College of Medicine, Fu Jen Catholic University, No. 510 Zhongzheng Rd., Xinzhuang Dist., New Taipei 24205, Taiwan.ORCID 0000-0003-0380-3282
Tsung-An TsaiDepartment of Anesthesiology, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei 24352, Taiwan.
Po-Heng ChenSchool of Medicine, College of Medicine, Fu Jen Catholic University, No. 510 Zhongzheng Rd., Xinzhuang Dist., New Taipei 24205, Taiwan.
Chao-Hsien SungSchool of Medicine, College of Medicine, Fu Jen Catholic University, No. 510 Zhongzheng Rd., Xinzhuang Dist., New Taipei 24205, Taiwan.ORCID 0000-0002-0461-2050
Chun-Hsien FuDepartment of Anesthesiology, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei 24352, Taiwan.ORCID 0000-0003-2007-8203
Jen-Hao LiuDepartment of Anesthesiology, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei 24352, Taiwan.
Chih-Li ChenSchool of Medicine, College of Medicine, Fu Jen Catholic University, No. 510 Zhongzheng Rd., Xinzhuang Dist., New Taipei 24205, Taiwan.ORCID 0000-0001-5818-6918

Funding

Fu Jen Catholic University Hospital PL202308043V, PL202408053VIrene and Paul Chair Professor ship, College of Medicine, Fu Jen Catholic University nonethe National Science and Technology Council of the Republic of China (Taiwan) MOST 109-2314-B-030-003 -My3
6 · The paper itself

Abstract

DRG adhesion is a key pathological feature of failed back surgery syndrome and a major cause of neuropathic pain. DRG, or epidural adhesion, commonly results from spinal surgery, leakage of disk material into the epidural space, or inflammation. To better mimic this clinical condition, we developed a novel and reliable animal model of DRG adhesion-induced neuropathic pain. Using this model, we investigated the therapeutic potential and underlying mechanisms of CLARIX FLO, a sterile, particulate human amniotic membrane and umbilical cord tissue product. Our results demonstrate that CLARIX FLO exerts significant analgesic and anti-inflammatory effects in the DRG adhesion model. The application of CLARIX FLO to the injured DRG markedly attenuated mechanical allodynia. CLARIX FLO treatment also reduced outer sheath thickening, suppressed the inflammatory microenvironment, and decreased hypersensitivity of isolectin B4-positive neurons. Mechanistically, CD44 was identified as a potential downstream mediator of CLARIX FLO. Furthermore, a high dose of HC-HA/PTX3, the key bioactive component of CLARIX FLO, effectively reversed mechanical allodynia and inflammation. Notably, CLARIX FLO inhibited the overexpression of TNF-α and TRPV1 adhering to the DRG. In this study, we demonstrated that CLARIX FLO effectively alleviates DRG adhesion-induced neuropathic pain through a CD44-TRPV1-dependent mechanism.

Indexed as

Ganglia, SpinalHyaluronan ReceptorsNeuralgiaSignal TransductionTRPV Cation ChannelsAnimalsDisease Models, AnimalHumansHyperalgesiaMaleRatsRats, Sprague-DawleyTissue AdhesionsTumor Necrosis Factor-alphaHyaluronan ReceptorsTRPV Cation ChannelsTumor Necrosis Factor-alphaanti-inflammationCLARIX FLOdorsal root ganglionneuropathic painoxidative regenerative cellulose

Identifiers

PMID41977284
PMCPMC13073902

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.