ArticleInternational journal of molecular sciences2026
Age-Related Changes as the Primary Driver of Pineal Gland Involution-A Morphological Study in Health and Disease.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Neuroglia Alterations in the Olfactory Bulbs in Patients with Schizophrenia: An Exploratory Postmortem Study.Life (Basel, Switzerland) · 2026Article
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4 authors.
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Abstract
The human pineal gland (PG) undergoes structural and cellular changes during the aging process, yet the underlying patterns and mechanisms remain insufficiently understood. In this study, we analyzed the lobular architecture and astrocytic network of the PG and identified two distinct pathways associated with normal aging. The first is characterized by an increase in astrocyte number within the pineal parenchyma, suggesting a compensatory role in supporting pinealocyte function. The second pathway involves disruption of the lobular structure, leading to a decline in the functional integrity of the gland. While pathological conditions such as neurodegenerative and psychiatric disorders may accelerate pineal degeneration and reduce melatonin production, our results suggest that normal aging is the principal factor driving this involutional process. These findings contribute to a deeper understanding of the morphological aging pathways of the pineal gland and their potential functional implications.
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