Evidence map›Paper›PMID 41977275›Full record

ReviewInternational journal of molecular sciences2026

Disruption of Synaptic Vesicle Trafficking in Alzheimer's and Parkinson's Disease: Mechanisms and Therapeutic Implication.

Youyang Zhu, Lianna Zhao, Yingming Li, Miao Tian, Yingdi Liao, Jinqing Huang, Peixin Guo, Yuhuan Xie

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Youyang ZhuFirst Clinical Medical College, Yunnan University of Chinese Medicine, Kunming 650500, China.
Lianna ZhaoCollege of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.
Yingming LiCollege of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.
Miao TianFirst Clinical Medical College, Yunnan University of Chinese Medicine, Kunming 650500, China.
Yingdi LiaoFirst Clinical Medical College, Yunnan University of Chinese Medicine, Kunming 650500, China.
Jinqing HuangCollege of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.
Peixin GuoThe College Based Key Laboratory of Yunnan in Aromatic Chinese Herbal Research, Kunming 650500, China.
Yuhuan XieThe College Based Key Laboratory of Yunnan in Aromatic Chinese Herbal Research, Kunming 650500, China.

Funding

National Natural Science Foundation of China 82060823National Natural Science Foundation of China 82074421Natural Science Foundation of Yunnan Province 202501AS070139Yunnan Collaborative Innovation Center for the Application of Aromatic Chinese Medicine N/AYunnan Provincial Department of Education 2024Y395Yunnan Science and Technology Talent and Platform Program 202105AG070012XS25032
6 · The paper itself

Abstract

Alzheimer's (AD) and Parkinson's disease (PD) are prominent neurodegenerative disorders characterized by early synaptic loss, which correlates more closely with clinical symptoms than neuronal death. This synaptic impairment is primarily driven by disruptions in synaptic vesicle (SV) trafficking, a critical process for maintaining synaptic integrity through a tightly regulated cycle involving clustering, docking-priming, Ca

Indexed as

Alzheimer DiseaseParkinson DiseaseSynaptic Vesiclesalpha-SynucleinAnimalsEndocytosisHumansProtein Transportalpha-SynucleinAlzheimer’s diseaseParkinson’s diseaseprotein aggregationSNARE complexsynaptic vesicle trafficking

Identifiers

PMID41977275
PMCPMC13073225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.