Evidence map›Paper›PMID 41977266›Full record

ArticleInternational journal of molecular sciences2026

Pro-Inflammatory Activation Promotes Atherogenic Endothelial Phenotype in Male and Female Human Umbilical Endothelial Vein Cells (HUVECs).

Mario Lorenz, Riwka Palant, Edith Oscherowa, Weam Karmid-Haj Hamoud, Jennifer A Kirwan, Sarah Trajkovski, Janine Wiebach, Raphaela Fritsche-Guenther, Haiyan Wu, Natalie Haritonow and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mario LorenzCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.ORCID 0000-0001-5267-4101
Riwka PalantCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Edith OscherowaCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Weam Karmid-Haj HamoudCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Jennifer A KirwanBerlin Institute of Health at Charité-Universitätsmedizin Berlin, BIH Metabolomics, Charitéplatz 1, 10117 Berlin, Germany.ORCID 0000-0002-5423-1651
Sarah TrajkovskiBerlin Institute of Health at Charité-Universitätsmedizin Berlin, BIH Metabolomics, Charitéplatz 1, 10117 Berlin, Germany.
Janine WiebachBerlin Institute of Health at Charité-Universitätsmedizin Berlin, BIH Metabolomics, Charitéplatz 1, 10117 Berlin, Germany.ORCID 0000-0002-7416-9859
Raphaela Fritsche-GuentherBerlin Institute of Health at Charité-Universitätsmedizin Berlin, BIH Metabolomics, Charitéplatz 1, 10117 Berlin, Germany.
Haiyan WuCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Natalie HaritonowCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Angelika VietzkeCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Elena KaschinaCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.ORCID 0000-0002-8966-5070
Wolfgang HenrichCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Julia TempDepartment of Urology, Eberhard Karls University of Tuebingen, 72076 Tuebingen, Germany.ORCID 0009-0001-9491-1205
Maria Luisa BarcenaDepartment of Urology, Eberhard Karls University of Tuebingen, 72076 Tuebingen, Germany.ORCID 0000-0003-1391-9262

Funding

Deutschen Zentrum für Herz‑Kreislauf‑Forschung DZHK Berlin, 81Z0100205German Heart Research Foundation F/03/22
6 · The paper itself

Abstract

Atherosclerosis, the leading global cause of death, is a chronic inflammatory vascular disease with higher prevalence and earlier onset in men than in women. This study aims to investigate sex differences in the atherogenic endothelial phenotype during early atherosclerosis processes by providing the first comprehensive analysis of hormone-independent responses in human umbilical vein endothelial cells (HUVECs) from opposite-sex twins. HUVECs underwent pro-inflammatory stimulation with TNF-α and supernatant from activated pro-inflammatory THP-1 cells, revealing distinct sex-specific patterns: mRNA expression of focal adhesion proteins

Indexed as

AtherosclerosisHuman Umbilical Vein Endothelial CellsInflammationCytokinesFemaleHumansMalePhenotypeTumor Necrosis Factor-alphaCytokinesTumor Necrosis Factor-alphacytokinesfocal proteinshuman umbilical vein endothelial cells (HUVECs)inflammationsex differences

Identifiers

PMID41977266
PMCPMC13073718

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.