Evidence map›Paper›PMID 41977236›Full record

ArticleInternational journal of molecular sciences2026

Soluble CD14 Levels Predict Liver Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Independently of Obesity and Type 2 Diabetes.

Ilaria Barchetta, Flavia Agata Cimini, Federica Sentinelli, Sara Dule, Valentina Frattina, Giulia Passarella, Maria Neve Hirsch, Alessandro Oldani, Marco Giorgio Baroni, Maria Gisella Cavallo

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ilaria BarchettaDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-0530-8568
Flavia Agata CiminiDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Federica SentinelliDepartment of Clinical Medicine, Public Health, Life and Environmental Sciences (MeSVA), University of L'Aquila, 67100 L'Aquila, Italy.
Sara DuleDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-5089-6963
Valentina FrattinaDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Giulia PassarellaDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Maria Neve HirschDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Alessandro OldaniDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0009-0001-7929-7390
Marco Giorgio BaroniDepartment of Clinical Medicine, Public Health, Life and Environmental Sciences (MeSVA), University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-3224-6078
Maria Gisella CavalloDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-6630-8049

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased intestinal permeability has been implicated in metabolic dysfunction-associated steatotic liver disease (MASLD), but its relationship with liver fibrosis independent of metabolic risk factors remains unclear. The aim of this study was to investigate the relationship between markers of gut-derived immune activation and liver fibrosis in individuals with metabolic disease. We enrolled 139 adults (48.8 ± 11 years; BMI 33.7 ± 9.5 kg/m

Indexed as

Diabetes Mellitus, Type 2Fatty LiverLipopolysaccharide ReceptorsLiver CirrhosisNon-alcoholic Fatty Liver DiseaseObesityAcute-Phase ProteinsAdultBiomarkersCarrier ProteinsFemaleHumansLipopolysaccharide-Binding ProteinMaleMembrane GlycoproteinsMiddle AgedAcute-Phase ProteinsBiomarkersCarrier ProteinsCD14 protein, humanLipopolysaccharide-Binding ProteinLipopolysaccharide ReceptorsMembrane Glycoproteinsendotoxemiagut–liver axisinnate immune activationintestinal permeabilitylipopolysaccharide-binding proteinliver fibrosisMASLDmetabolic diseasenon-invasive biomarkerssoluble CD14

Identifiers

PMID41977236
PMCPMC13074000

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.