Evidence map›Paper›PMID 41977217›Full record

ArticleInternational journal of molecular sciences2026

Dihydroartemisinin Induces Ferroptosis in Uveal Melanoma Cells Through the HO-1 and xCT/GPX4 Signaling Pathways.

Yuxuan Zhao, Chen Hou, Lirong Xiao, Longqian Liu, Naihong Yan

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuxuan ZhaoResearch Laboratory of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China.
Chen HouDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China.
Lirong XiaoResearch Laboratory of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID 0000-0001-7378-2195
Longqian LiuDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China.
Naihong YanResearch Laboratory of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID 0000-0002-3547-3436

Funding

Key Research and Development Project of Sichuan Science and Technology Department 024YFFK0379Science and Technology Department of Sichuan Province 2024NSFSC1720
6 · The paper itself

Abstract

Uveal melanoma (UM) represents an uncommon intraocular malignancy with high aggressiveness. Dysregulation of ferroptosis has been associated with UM progression. Dihydroartemisinin (DHA), a natural derivative of

Indexed as

Amino Acid Transport System y+ArtemisininsFerroptosisHeme Oxygenase-1MelanomaPhospholipid Hydroperoxide Glutathione PeroxidaseSignal TransductionUveal NeoplasmsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansLipid PeroxidationMitochondriaReactive Oxygen SpeciesUveal MelanomaAmino Acid Transport System y+ArtemisininsartenimolHeme Oxygenase-1HMOX1 protein, humanPhospholipid Hydroperoxide Glutathione PeroxidaseReactive Oxygen SpeciesSLC7A11 protein, humanferroptosisheme oxygenase 1natural productuveal melanoma

Identifiers

PMID41977217
PMCPMC13073528

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.