Evidence map›Paper›PMID 41977215›Full record

ArticleInternational journal of molecular sciences2026

Role of the Glycine Transporter GlyT2 in the Neuronal Differentiation of PC12 Cells.

Jorge Sarmiento-Jiménez, Beatriz Morales-González, Enrique Núñez, Elena Martínez-Blanco, Francisco Zafra, Francisco Javier Díez-Guerra, Beatriz López-Corcuera

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jorge Sarmiento-JiménezDepartamento de Biología Molecular, Instituto de Biología Molecular (IUBM), Centro de Biología Molecular "Severo Ochoa", Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, 28049 Madrid, Spain.ORCID 0009-0004-8238-8885
Beatriz Morales-GonzálezDepartamento de Biología Molecular, Instituto de Biología Molecular (IUBM), Centro de Biología Molecular "Severo Ochoa", Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, 28049 Madrid, Spain.ORCID 0009-0003-5123-9011
Enrique NúñezDepartamento de Biología Molecular, Instituto de Biología Molecular (IUBM), Centro de Biología Molecular "Severo Ochoa", Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, 28049 Madrid, Spain.
Elena Martínez-BlancoDepartamento de Biología Molecular, Instituto de Biología Molecular (IUBM), Centro de Biología Molecular "Severo Ochoa", Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, 28049 Madrid, Spain.ORCID 0000-0003-3683-5096
Francisco ZafraDepartamento de Biología Molecular, Instituto de Biología Molecular (IUBM), Centro de Biología Molecular "Severo Ochoa", Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, 28049 Madrid, Spain.
Francisco Javier Díez-GuerraDepartamento de Biología Molecular, Instituto de Biología Molecular (IUBM), Centro de Biología Molecular "Severo Ochoa", Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, 28049 Madrid, Spain.ORCID 0000-0003-1707-4519
Beatriz López-CorcueraDepartamento de Biología Molecular, Instituto de Biología Molecular (IUBM), Centro de Biología Molecular "Severo Ochoa", Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, 28049 Madrid, Spain.ORCID 0000-0002-0383-4241

Funding

Fundación Ramón Areces CBM Severo OchoaFundación Ramón Areces CIVP20A6612MCIN/AEI/10.13039/501100011033 CEX2021-001154-SMCIN/AEI/10.13039/501100011033 PID2020-119399RB-I00MCIN/AEI/10.13039/501100011033 PID2023-150608OB-I00
6 · The paper itself

Abstract

Hyperekplexia is a neurologic disorder of marked perinatal significance. Affected neonates display generalized hypertonia and exaggerated startle reflex in response to innocuous stimuli, potentially leading to life-threatening apneic episodes. Although symptom severity typically diminishes during the first year of life, affected individuals often continue to exhibit disabling motor dysfunction and frequent unprotected falls throughout adulthood. Currently, no targeted therapeutic interventions are available. The pathophysiology involves partial or complete disruption of inhibitory glycinergic neurotransmission. Mutations in the gene encoding the neuronal glycine transporter GlyT2 (

Indexed as

Cell DifferentiationGlycine Plasma Membrane Transport ProteinsNeurogenesisNeuronsAnimalsCalciumGlycinePC12 CellsRatsCalciumGlycineGlycine Plasma Membrane Transport ProteinsSlc6a5 protein, ratdevelopmentGAP-43glycine transportGlyT2hyperekplexianeuron differentiationPC12 cells

Identifiers

PMID41977215
PMCPMC13073545

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.