Evidence map›Paper›PMID 41977209›Full record

ArticleInternational journal of molecular sciences2026

From Synthesis to Mechanism: Biological Evaluation of a p-Toluidine-Based Thiazolidinone-Quinoline VEGFR-2 Candidate Supported by CADD.

Emad Manni, Modather F Hussein, Sara Elkady, Adel A-H Abdel-Rahman, Mohamed A Hawata, Wael A El-Sayed, Ahmed F El-Sayed, Hagar S El-Hema

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emad ManniDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi Arabia.
Modather F HusseinChemistry Department, College of Science, Jouf University, P.O. Box 2014, Sakaka 72341, Saudi Arabia.ORCID 0000-0003-3664-2745
Sara ElkadyChemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom 32511, Egypt.
Adel A-H Abdel-RahmanChemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom 32511, Egypt.
Mohamed A HawataChemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom 32511, Egypt.
Wael A El-SayedPhotochemistry Department, National Research Centre, Dokki, Giza 12622, Egypt.ORCID 0000-0002-8232-1830
Ahmed F El-SayedMicrobial Genetics Department, Biotechnology Research Institute, National Research Centre, Giza 12622, Egypt.ORCID 0000-0002-5312-4870
Hagar S El-HemaBasic Science Department (Chemistry), Thebes Higher Institute for Engineering, Thebes Academy, Maadi 11434, Egypt.ORCID 0009-0000-3841-6122

Funding

The Deanship of Graduate Studies and Scientific Research at Jouf University DGSSR-2024-02-02146
6 · The paper itself

Abstract

In response to recent advances in computer-aided drug discovery (CADD) enabled by high-performance computing, computational approaches were employed to support and rationalize the investigation of a VEGFR-2-targeted anticancer candidate, combining molecular-level modeling with experimental validation. Initial in silico ADMET profiling and molecular docking were conducted to support the evaluation of drug-like properties and target engagement within a series of

Indexed as

Antineoplastic AgentsProtein Kinase InhibitorsQuinolinesThiazolidinesVascular Endothelial Growth Factor Receptor-2ApoptosisCell Line, TumorCell MovementCell ProliferationComputer-Aided DesignDrug DiscoveryHep G2 CellsHumansMolecular Docking SimulationMolecular Dynamics SimulationAntineoplastic AgentsKDR protein, humanProtein Kinase InhibitorsQuinolinesThiazolidinesVascular Endothelial Growth Factor Receptor-2computer-aided drug discovery (CADD)density functional theory (DFT)lead optimizationmolecular dockingmolecular dynamics simulationp-toluidine-based thiazolidinone-quinoline hybridsVEGFR-2 inhibition

Identifiers

PMID41977209
PMCPMC13073930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.