Evidence map›Paper›PMID 41977198›Full record

ArticleInternational journal of molecular sciences2026

HDAC6 Promotes Host Defense Against Chlamydial Lung Infections by Regulating M2-Th2 Responses.

Jinxi Yu, Shuaini Yang, Xiaoyu Zha, Yuqing Tuo, Ruoyuan Sun, Hong Zhang, Lu Tan, Hong Bai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jinxi YuKey Laboratory of Immune Microenvironment and Disease of the Ministry of Education, Tianjin Institute of Immunology, Department of Immunology, Tianjin Medical University, Tianjin 300070, China.
Shuaini YangKey Laboratory of Immune Microenvironment and Disease of the Ministry of Education, Tianjin Institute of Immunology, Department of Immunology, Tianjin Medical University, Tianjin 300070, China.
Xiaoyu ZhaKey Laboratory of Immune Microenvironment and Disease of the Ministry of Education, Tianjin Institute of Immunology, Department of Immunology, Tianjin Medical University, Tianjin 300070, China.
Yuqing TuoKey Laboratory of Immune Microenvironment and Disease of the Ministry of Education, Tianjin Institute of Immunology, Department of Immunology, Tianjin Medical University, Tianjin 300070, China.
Ruoyuan SunKey Laboratory of Immune Microenvironment and Disease of the Ministry of Education, Tianjin Institute of Immunology, Department of Immunology, Tianjin Medical University, Tianjin 300070, China.
Hong ZhangKey Laboratory of Immune Microenvironment and Disease of the Ministry of Education, Tianjin Institute of Immunology, Department of Immunology, Tianjin Medical University, Tianjin 300070, China.
Lu TanKey Laboratory of Immune Microenvironment and Disease of the Ministry of Education, Tianjin Institute of Immunology, Department of Immunology, Tianjin Medical University, Tianjin 300070, China.
Hong BaiKey Laboratory of Immune Microenvironment and Disease of the Ministry of Education, Tianjin Institute of Immunology, Department of Immunology, Tianjin Medical University, Tianjin 300070, China.

Funding

Key Program of Tianjin Science and Technology Commission 15JCZDJC34900Key Program of Tianjin Science and Technology Commission 19JCZDJC35800National Natural Science Foundation of China 31070797National Natural Science Foundation of China 31870889
6 · The paper itself

Abstract

Histone deacetylase 6 (HDAC6), a member of the class IIb HDAC family, plays a crucial role in epigenetic regulation and cytoskeletal dynamics, while participating in host anti-infective immune responses. However, its precise functions and mechanisms during

Indexed as

Chlamydia InfectionsChlamydia muridarumHistone Deacetylase 6Th2 CellsAnimalsCytokinesGATA3 Transcription FactorLungMacrophagesMiceMice, Inbred C57BLMice, KnockoutSTAT6 Transcription FactorCytokinesGATA3 Transcription FactorHdac6 protein, mouseHistone Deacetylase 6STAT6 Transcription FactorChlamydia muridarumHDAC6macrophage polarizationrespiratory infectionT cell differentiationTh2-M2 responses

Identifiers

PMID41977198
PMCPMC13073687

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.