ArticleInternational journal of molecular sciences2026
Dynamics of Human Endogenous Retroviruses Expression, Proviral Load and Systemic Inflammatory Status Modulated by Physical Exercise and Aging.
Michelly Damasceno da Silva, Pablo Fortunato da Silva, Samuel Nascimento Santos, Matheus Esteves Fernandes, Maria Kauanne de Oliveira Santos, Camila Malta Romano, Jonatas Bussador do Amaral, Marina Tiemi Shio, Gislene Rocha Amirato, Carlos André Freitas Dos Santos and 3 more
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
13 authors.
Michelly Damasceno da SilvaPost-Graduation Program in Health Sciences, Santo Amaro University, Rua Isabel Schimitt, 540, São Paulo 04743-030, Brazil.
Pablo Fortunato da SilvaPost-Graduation Program in Health Sciences, Santo Amaro University, Rua Isabel Schimitt, 540, São Paulo 04743-030, Brazil.ORCID 0009-0004-3527-5749 Samuel Nascimento SantosPost-Graduation Program in Health Sciences, Santo Amaro University, Rua Isabel Schimitt, 540, São Paulo 04743-030, Brazil.
Matheus Esteves FernandesPost-Graduation Program in Health Sciences, Santo Amaro University, Rua Isabel Schimitt, 540, São Paulo 04743-030, Brazil.
Maria Kauanne de Oliveira SantosPost-Graduation Program in Health Sciences, Santo Amaro University, Rua Isabel Schimitt, 540, São Paulo 04743-030, Brazil.
Camila Malta RomanoHospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo 05508-070, Brazil.ORCID 0000-0003-4550-1987 Jonatas Bussador do AmaralEnt Research Laboratory, Department of Otorhinolaryngology-Head and Neck Surgery, Federal University of Sao Paulo, São Paulo 04039-020, Brazil.ORCID 0000-0001-5819-0474 Marina Tiemi ShioPost-Graduation Program in Health Sciences, Santo Amaro University, Rua Isabel Schimitt, 540, São Paulo 04743-030, Brazil.
Gislene Rocha AmiratoMane Garrincha Sport Education Center, Sports Department of the Municipality of São Paulo (SEME), São Paulo 04039-034, Brazil.
Carlos André Freitas Dos SantosDiscipline of Geriatrics and Gerontology, Department of Medicine, Paulista School of Medicine, Federal University of São Paulo, São Paulo 04039-020, Brazil.ORCID 0000-0001-5822-7791 Saulo GilPost-Graduation Program in Health Sciences, Santo Amaro University, Rua Isabel Schimitt, 540, São Paulo 04743-030, Brazil.ORCID 0000-0001-9050-0073 André Luis Lacerda BachiPost-Graduation Program in Health Sciences, Santo Amaro University, Rua Isabel Schimitt, 540, São Paulo 04743-030, Brazil.ORCID 0000-0001-8266-1416 Luiz Henrique da Silva NaliPost-Graduation Program in Health Sciences, Santo Amaro University, Rua Isabel Schimitt, 540, São Paulo 04743-030, Brazil.ORCID 0000-0002-8365-9796 Funding
Conselho Nacional de Desenvolvimento Científico e Tecnológico 303526/2024-6Fundação de Amparo à Pesquisa do Estado de São Paulo 23/08773-0Fundação de Amparo à Pesquisa do Estado de São Paulo 24/05197-1Fundação de Amparo à Pesquisa do Estado de São Paulo 24/05545-0
6 · The paper itselfAbstract
Human endogenous retroviruses (HERVs), remnants of ancient germline infections, constitute ~8% of the human genome. Although mostly silenced, these elements can be expressed and play physiological or pathological roles. We investigated HERV expression dynamics, proviral load, and systemic inflammatory status in young and older adults, as well as the impact of regular physical exercise. PBMC and serum samples were collected from 30 young controls (YC), 30 inactive older adults (INAC) and 30 regularly exercising older adults (REG). Expression of HERV-W, -K, -H, Syncytin-1 and -2 was assessed by qPCR using the -2ΔΔCt method, and proviral load (HERV-W, -K, -H) was estimated by relative copy number. Serum cytokines (IL-1β, IL-6, IL-17, TNF-α, IFN-γ, IL-10) were quantified by ELISA. Statistical significance was set at
Indexed as
AgingEndogenous RetrovirusesExerciseInflammationProvirusesViral LoadAdultAgedCytokinesFemaleHumansMaleMiddle AgedYoung AdultCytokinesagingcytokinesHERVsinflammationregular physical exercise
Identifiers
PMID41977197
PMCPMC13073308
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