Evidence map›Paper›PMID 41977189›Full record

ArticleInternational journal of molecular sciences2026

Exosome-Mediated miRNA Delivery Restores Early Differentiation and Survival Programs in DGCR8-Deficient Mouse Embryonic Stem Cells.

Tae-Won Ha, Hyun Kyu Kim, Dongyue No, Jeong Bin Lee, Ahyeon Kim, Bomi Kim, Yena Song, Munkhzul Choijamts, Youngsok Choi, Mihye Lee and 1 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tae-Won HaSoonchunhyang Institute of Medi-bio Science (SIMS), Soon Chun Hyang University, Cheonan 31151, Republic of Korea.ORCID 0000-0001-7552-822X
Hyun Kyu KimSoonchunhyang Institute of Medi-bio Science (SIMS), Soon Chun Hyang University, Cheonan 31151, Republic of Korea.
Dongyue NoDepartment of Stem Cell and Regenerative Biotechnology, KU Institute of Science and Technology, The Institute of Advanced Regenerative Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.
Jeong Bin LeeDepartment of Stem Cell and Regenerative Biotechnology, KU Institute of Science and Technology, The Institute of Advanced Regenerative Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.
Ahyeon KimDepartment of Stem Cell and Regenerative Biotechnology, KU Institute of Science and Technology, The Institute of Advanced Regenerative Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.
Bomi KimDepartment of Stem Cell and Regenerative Biotechnology, KU Institute of Science and Technology, The Institute of Advanced Regenerative Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.
Yena SongSoonchunhyang Institute of Medi-bio Science (SIMS), Soon Chun Hyang University, Cheonan 31151, Republic of Korea.
Munkhzul ChoijamtsSoonchunhyang Institute of Medi-bio Science (SIMS), Soon Chun Hyang University, Cheonan 31151, Republic of Korea.ORCID 0000-0002-9239-366X
Youngsok ChoiDepartment of Stem Cell and Regenerative Biotechnology, KU Institute of Science and Technology, The Institute of Advanced Regenerative Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.ORCID 0000-0002-3862-4105
Mihye LeeSoonchunhyang Institute of Medi-bio Science (SIMS), Soon Chun Hyang University, Cheonan 31151, Republic of Korea.
Man Ryul LeeDepartment of Stem Cell and Regenerative Biotechnology, KU Institute of Science and Technology, The Institute of Advanced Regenerative Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.ORCID 0000-0002-2351-9679

Funding

This research was supported by the "Regional Innovation System & Education (RISE)" through the Seoul RISE Center, funded by the Ministry of Education 2025-RISE-01-001-04 & 05This study was supported by the National Research Foundation of Korea RS-2023-00220207
6 · The paper itself

Abstract

Pluripotent stem cell (PSC) differentiation is orchestrated by intricate autocrine and paracrine signaling networks. Among these, exosomes, key components of the cellular secretome, are implicated as crucial mediators of intercellular communication via delivery of bioactive molecules, including microRNAs (miRNAs). This study investigated the role of exosomal miRNAs in stem cell differentiation using

Indexed as

Cell DifferentiationExosomesMicroRNAsMouse Embryonic Stem CellsRNA-Binding ProteinsAnimalsApoptosisCell SurvivalMiceSignal TransductionDgcr8 protein, mouseMicroRNAsRNA-Binding ProteinsDiGeorge syndrome critical region 8 (Dgcr8)exosomemicroRNA (miRNA)morphogenetic apoptosismouse embryonic stem cells

Identifiers

PMID41977189
PMCPMC13073286

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.