Evidence map›Paper›PMID 41977140›Full record

ArticleInternational journal of molecular sciences2026

Anti-GPI scFv as a Promising Tool for Intervention Against Cerebral Malaria in Mice.

Sandra Gabriela Klein, Kelem Cristina Pereira Mota, Bruna Cristina Borges, Mylla Spirandelli Vieira, Matheus Morais Neves, Ludmilla Silva Mendes, Flávia Batista Ferreira, Isabela Lemos de Lima, Fabiana de Almeida Araújo Santos, Luciana Machado Bastos and 3 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sandra Gabriela KleinBiotechnology Laboratory in Experimental Models-LABME, Federal University of Uberlândia, Uberlândia 38402-018, MG, Brazil.
Kelem Cristina Pereira MotaLaboratory of Nanobiotechnology (NANOs), Federal University of Uberlândia, Uberlândia 38402-018, MG, Brazil.
Bruna Cristina BorgesBiotechnology Laboratory in Experimental Models-LABME, Federal University of Uberlândia, Uberlândia 38402-018, MG, Brazil.
Mylla Spirandelli VieiraBiotechnology Laboratory in Experimental Models-LABME, Federal University of Uberlândia, Uberlândia 38402-018, MG, Brazil.
Matheus Morais NevesBiotechnology Laboratory in Experimental Models-LABME, Federal University of Uberlândia, Uberlândia 38402-018, MG, Brazil.
Ludmilla Silva MendesBiotechnology Laboratory in Experimental Models-LABME, Federal University of Uberlândia, Uberlândia 38402-018, MG, Brazil.
Flávia Batista FerreiraBiotechnology Laboratory in Experimental Models-LABME, Federal University of Uberlândia, Uberlândia 38402-018, MG, Brazil.
Isabela Lemos de LimaBiotechnology Laboratory in Experimental Models-LABME, Federal University of Uberlândia, Uberlândia 38402-018, MG, Brazil.ORCID 0000-0003-0953-487X
Fabiana de Almeida Araújo SantosLaboratory of Nanobiotechnology (NANOs), Federal University of Uberlândia, Uberlândia 38402-018, MG, Brazil.ORCID 0000-0002-5049-4075
Luciana Machado BastosLaboratory of Nanobiotechnology (NANOs), Federal University of Uberlândia, Uberlândia 38402-018, MG, Brazil.
Wânia Rezende LimaBiotechnology Laboratory in Experimental Models-LABME, Federal University of Uberlândia, Uberlândia 38402-018, MG, Brazil.
Luiz Ricardo Goulart FilhoLaboratory of Nanobiotechnology (NANOs), Federal University of Uberlândia, Uberlândia 38402-018, MG, Brazil.ORCID 0000-0002-1803-4861
Murilo Vieira da SilvaBiotechnology Laboratory in Experimental Models-LABME, Federal University of Uberlândia, Uberlândia 38402-018, MG, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 0Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) APQ-00660-21/2021-1Ministério Público do Trabalho de Uberlândia (MPT) 0National Institute of Science and Technology in Theranostics and Nanobiotechnology - INCT-Teranano, Brazil 403193/2022-2National Institute of Science and Technology in Theranostics and Nanobiotechnology - INCT-Teranano, Brazil APQ-03613-17Rede Mineira de Biotecnologia em Modelos Experimentais (RMBME) 0Universidade Federal de Uberlândia (UFU) 0
6 · The paper itself

Abstract

Malaria remains a major global health challenge. While treatments targeting parasite replication exist, effective interventions for neurological manifestations are scarce, necessitating new strategies for cerebral malaria. In this study, we investigated the effect of a single-chain variable fragment (scFv) against glycosylphosphatidylinositol (GPI) as an intervention tool to mitigate the effects of

Indexed as

GlycosylphosphatidylinositolsMalaria, CerebralPlasmodium bergheiSingle-Chain AntibodiesAnimalsBrainCytokinesDisease Models, AnimalFemaleMiceMice, Inbred C57BLParasitemiaCytokinesGlycosylphosphatidylinositolsSingle-Chain Antibodiesexperimental cerebral malariaglycosylphosphatidylinositolnanobiotechnologyPlasmodium berghei ANKAsingle-chain variable fragment

Identifiers

PMID41977140
PMCPMC13073753

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.