Evidence map›Paper›PMID 41976512›Full record

ArticleFoods (Basel, Switzerland)2026

Determination of Glycidol in Soy Sauce Using p-Dimethylaminophenol Derivatization Coupled with Liquid Chromatography-Tandem Mass Spectrometry.

Yifan Zhao, Peng Wang, Longlong Wang, Lixia Qin, Hai Chi, Guangxin Yang, Xiaosheng Shen, Chengqi Fan, Xiaoqing Tian, Mian Hasnain Nawaz and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yifan ZhaoEast China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China.
Peng WangEast China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China.
Longlong WangEast China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China.
Lixia QinSchool of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, China.
Hai ChiKey Laboratory of Protection and Utilization of Aquatic Germplasm Resource, Liaoning Ocean and Fisheries Science Research Institute, Dalian 116023, China.ORCID 0000-0003-3072-511X
Guangxin YangEast China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China.ORCID 0000-0001-6320-6194
Xiaosheng ShenEast China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China.
Chengqi FanEast China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China.
Xiaoqing TianEast China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China.
Mian Hasnain NawazInterdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS University Islamabad, Lahore Campus, Lahore 54000, Pakistan.ORCID 0000-0002-6648-0778
Cong KongEast China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China.ORCID 0000-0001-8084-2133

Funding

Science and Technology Innovation Special Program of the Liaoning Academy of Agricultural Sciences 2025-HBZ-1111 and 2026JC4037the Central Public-interest Scientific Institution Basal Research Fund, ECSFR, CAFS 2024YC03the National Natural Science Foundation of China 31701698the Science and Technology Commission of Shanghai Municipality 22Y42201400the Shanghai Municipal Commission of Agriculture and Rural Affairs 2024-02-08-00-12-F00033
6 · The paper itself

Abstract

Glycidol, a probable human carcinogen, remains an under-investigated process contaminant in soy sauce. This study developed a sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for its determination in this complex condiment. The approach combined chemical derivatization with p-Dimethylaminophenol hydrochloride for analyte stabilization with an optimized sample pretreatment using a custom-packed activated carbon solid-phase extraction (SPE) cartridge effectively removed matrix interferences, and performing the derivatization at pH 6.5 prevented conversion of 2- and 3-monochloropropanediol (2-MCPD and 3-MCPD) into glycidol, ensuring high specificity and accuracy. This approach shows broad linearity from 1 to at least 100 ng/mL (R

Indexed as

carbon yarnderivatizationfood contaminantglycidolHPLC-MS/MSp-Dimethylaminophenolsoy sauce

Identifiers

PMID41976512
PMCPMC13073954

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.