Evidence map›Paper›PMID 41976393›Full record

ReviewCancers2026

Pediatric Spinal Atypical Teratoid Rhabdoid Tumor: Recent Advances in Biology and Management Options.

Ruby Siada, Kaushik Banerjee, Payal Malhotra, Mohannad Ibrahim, Daniel C Moreira, John R Prensner, Santhosh A Upadhyaya

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ruby SiadaDepartment of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.
Kaushik BanerjeeDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Payal MalhotraDepartment of Pediatric Hematology-Oncology & BMT, Rajiv Gandhi Cancer Institute & Research Centre, Delhi 110085, India.
Mohannad IbrahimDepartment of Radiology, University of Michigan, Ann Arbor, MI 48109, USA.
Daniel C MoreiraDepartment of Oncology, Division of Neuro-Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
John R PrensnerDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Santhosh A UpadhyayaDepartment of Pediatrics, Division of Pediatric Hematology Oncology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-6101-149X

Funding

Deciphering non-canonical translation in high risk medulloblastomaK08CA263552 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI John Prensner · 2022 to 2026
$1.2M
NCI NIH HHS K08 CA263552
6 · The paper itself

Abstract

Atypical teratoid rhabdoid tumor (AT/RT) is a rare, highly aggressive embryonal central nervous system malignancy occurring predominately in infants and toddlers. Spinal AT/RT (spAT/RT) cases are even more limited, and as a result, little is known regarding prognostic factors and optimal treatment regimens. Molecularly, AT/RT is divided into three groups: AT/RT-SHH, AT/RT-TYR and AT/RT-MYC. spAT/RT is predominantly of the MYC subtype. Additionally, a third of patients with AT/RT have a germline Rhabdoid Tumor Predisposition Syndrome (RTPS) that increases the likelihood of developing additional rhabdoid tumors, including renal rhabdoid tumors. Due to the rarity of these tumors, there is a lack of consensus on treatment strategies to be employed. This review paper details the published literature on spAT/RT, with particular emphasis on the recent advances in understanding the biology of these aggressive tumors and currently available therapeutic options, and highlights the challenges associated with the management of this extremely rare condition.

Indexed as

AT/RT-MYCatypical teratoid rhabdoid tumorintradural tumorpediatric spinal cord tumor

Identifiers

PMID41976393
PMCPMC13072098

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.