ReviewCancers2026
Photodynamic Therapy-Based Strategies Targeted at Cancer Stem Cells: A Scoping Review.
Review in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
A major challenge in cancer treatment is the presence of cancer stem cells (CSC), which play a significant role in therapeutic resistance, metastatic progression, and tumor relapse, highlighting their importance as therapeutic targets. Photodynamic therapy (PDT) can be a valuable strategy for targeting CSC by increasing reactive oxygen species via light-activated photosensitizers, thereby counteracting CSC features of resistance. Therefore, this manuscript reviews the existing evidence on PDT-based approaches targeted at CSC. The literature search was conducted using the Medline (through PubMed), Web of Science, and Embase databases. The inclusion criteria were in vitro, in vivo, and clinical studies addressing PDT-based therapeutic strategies targeting CSC. A total of 37 publications were included in this review. From this analysis, we identified several studies with CSC-associated targets, delivery of PDT systems to CSC, novel nanoplatforms that disrupted the CSC microenvironment, and combined strategies to enhance PDT efficacy. The existing strategies have shown success in reducing CSC populations across different cancers by decreasing viability and tumor growth, as well as limiting stemness properties. However, some technical and biological constraints can limit translation, and, to the best of our knowledge, no clinical studies have been reported.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.