Evidence map›Paper›PMID 41976329›Full record

ArticleCancers2026

Prognostic Potential of the NRF2 Transcription Factor in Canine Mammary Neoplasms.

Vitor de Moraes Pina de Carvalho, Anna Hielm-Björkman, Karine Araújo Damasceno, Thanielle Novaes Fontes, Carlos Humberto da Costa Vieira-Filho, Simone Nunes, Diego Carlos Dos Reis, Robin Moore, Stella Maria Barrouin-Melo, Geovanni Dantas Cassali and 1 more

Abstract read
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vitor de Moraes Pina de CarvalhoResearch Center on Mammary Oncology (NPqOM/HOSPMEV), Federal University of Bahia, Salvador 40170-110, Bahia, Brazil.ORCID 0000-0003-3315-3807
Anna Hielm-BjörkmanDogRisk Research Group, Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, 00790 Helsinki, Finland.ORCID 0000-0003-1343-3473
Karine Araújo DamascenoResearch Center on Mammary Oncology (NPqOM/HOSPMEV), Federal University of Bahia, Salvador 40170-110, Bahia, Brazil.
Thanielle Novaes FontesResearch Center on Mammary Oncology (NPqOM/HOSPMEV), Federal University of Bahia, Salvador 40170-110, Bahia, Brazil.
Carlos Humberto da Costa Vieira-FilhoResearch Center on Mammary Oncology (NPqOM/HOSPMEV), Federal University of Bahia, Salvador 40170-110, Bahia, Brazil.
Simone NunesResearch Center on Mammary Oncology (NPqOM/HOSPMEV), Federal University of Bahia, Salvador 40170-110, Bahia, Brazil.
Diego Carlos Dos ReisDivision of Molecular Pathology, The Institute of Cancer Research, London SM2 5NG, UK.ORCID 0000-0002-9676-7745
Robin MooreDogRisk Research Group, Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, 00790 Helsinki, Finland.ORCID 0000-0001-8556-0899
Stella Maria Barrouin-MeloResearch Center on Mammary Oncology (NPqOM/HOSPMEV), Federal University of Bahia, Salvador 40170-110, Bahia, Brazil.ORCID 0000-0003-3501-7366
Geovanni Dantas CassaliLaboratory of Comparative Pathology, Department of General Pathology, Federal University of Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, Brazil.ORCID 0000-0002-5650-6743
Alessandra Estrela-LimaResearch Center on Mammary Oncology (NPqOM/HOSPMEV), Federal University of Bahia, Salvador 40170-110, Bahia, Brazil.ORCID 0000-0002-9879-7999

Funding

Fundação de Amparo à Pesquisa do Estado da Bahia Proc. no BOL0147/2021Fundação de Amparo à Pesquisa do Estado de Minas Gerais RED-00031-21National Council for Scientific and Technological Development Proc. 303368/2021-7National Council for Scientific and Technological Development Proc. 310248/2021-3
6 · The paper itself

Abstract

Research based on the similarities between canine and human mammary tumors should extend beyond clinical, pathophysiological, epidemiological, and histopathological characteristics to include applicable molecular markers with prognostic significance. However, despite shared similarities, important differences must also be considered in comparative and translational studies. The nuclear erythroid 2-related factor (NRF2), a nuclear transcription factor that regulates the expression of antioxidant proteins, is pathologically activated during carcinogenesis. The role of NRF2 in human breast cancer is well established, making it a potential prognostic marker.

Indexed as

biomarkerbreast cancerdogH-scoreoxidative stresstranscription factor

Identifiers

PMID41976329
PMCPMC13072221

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.