Evidence map›Paper›PMID 41976317›Full record

ArticleCancers2026

Clinical Utility of Belay Summit™ Cerebrospinal Fluid Test to Inform Diagnosis and Management of Central Nervous System Cancer-A Single Institution Case Series.

Michael Youssef, Alexandra Larson, Vindhya Udhane, Zhixin Jiang, Daniel Lim, Jennifer N Adams, Rakshitha Jagadish, Anthony Acevedo, Brett A Domagala, Samantha A Vo and 7 more

Abstract read
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Michael YoussefDepartment of Neurology and the Department of Hematology and Oncology at UT Southwestern Medical Center, Dallas, TX 75235, USA.ORCID 0000-0003-4364-5573
Alexandra LarsonBelay Diagnostics, 1375 W. Fulton St, Suite 530, Chicago, IL 60607, USA.
Vindhya UdhaneBelay Diagnostics, 1375 W. Fulton St, Suite 530, Chicago, IL 60607, USA.
Zhixin JiangDepartment of Neurology and the Department of Hematology and Oncology at UT Southwestern Medical Center, Dallas, TX 75235, USA.
Daniel LimDepartment of Neurology and the Department of Hematology and Oncology at UT Southwestern Medical Center, Dallas, TX 75235, USA.
Jennifer N AdamsBelay Diagnostics, 1375 W. Fulton St, Suite 530, Chicago, IL 60607, USA.ORCID 0009-0005-2998-1070
Rakshitha JagadishBelay Diagnostics, 1375 W. Fulton St, Suite 530, Chicago, IL 60607, USA.
Anthony AcevedoBelay Diagnostics, 1375 W. Fulton St, Suite 530, Chicago, IL 60607, USA.
Brett A DomagalaBelay Diagnostics, 1375 W. Fulton St, Suite 530, Chicago, IL 60607, USA.ORCID 0009-0004-4136-8634
Samantha A VoBelay Diagnostics, 1375 W. Fulton St, Suite 530, Chicago, IL 60607, USA.
Tarin PeltierBelay Diagnostics, 1375 W. Fulton St, Suite 530, Chicago, IL 60607, USA.
Daniel SanchezBelay Diagnostics, 1375 W. Fulton St, Suite 530, Chicago, IL 60607, USA.
Viriya KeoBelay Diagnostics, 1375 W. Fulton St, Suite 530, Chicago, IL 60607, USA.ORCID 0000-0002-3256-5992
Julianna ErnstBelay Diagnostics, 1375 W. Fulton St, Suite 530, Chicago, IL 60607, USA.
Kala F SchilterBelay Diagnostics, 1375 W. Fulton St, Suite 530, Chicago, IL 60607, USA.ORCID 0000-0001-8061-0842
Qian NieBelay Diagnostics, 1375 W. Fulton St, Suite 530, Chicago, IL 60607, USA.
Honey V ReddiBelay Diagnostics, 1375 W. Fulton St, Suite 530, Chicago, IL 60607, USA.ORCID 0000-0003-1280-9993

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCytology from cerebrospinal fluid (CSF) is standard-of-care to detect central nervous system (CNS) cancers but suffers from low-sensitivity and lacks associated molecular information, often requiring brain biopsy or resection to obtain. Belay Diagnostics offers analytically and clinically validated CSF-based tests to support the diagnosis and management of primary and secondary CNS cancers. However, the clinical utility (CU) of these assays has not been previously evaluated.

methodsThis retrospective study presents a real-world, single institution experience of using the Belay Summit liquid biopsy test for all orders received (

resultsThe cohort included 120 patients with suspected or previously diagnosed primary (

conclusionsThe Belay Summit test provides clinically meaningful information to support physician decision-making for the diagnosis and management of primary and secondary CNS tumors, especially in cases where tissue sampling is infeasible.

Indexed as

clinical utilityCNS tumorsCSF liquid biopsygenomic alterationssummit test

Identifiers

PMID41976317
PMCPMC13072157

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.