Evidence map›Paper›PMID 41976312›Full record

ReviewCancers2026

Role of MRI in Imaging Assessment of Radiation-Based Treatment of Hepatocellular Carcinoma.

Liang Meng Loy, Guo Yuan How, Uei Pua, Han Hwee Lawrence Quek, Cher Heng Tan

Abstract readReview
In one paragraph

Review in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Liang Meng LoyKhoo Teck Puat Hospital, Singapore 768828, Singapore.ORCID 0000-0002-3205-5706
Guo Yuan HowTan Tock Seng Hospital, Singapore 308433, Singapore.ORCID 0000-0002-2104-899X
Uei PuaTan Tock Seng Hospital, Singapore 308433, Singapore.
Han Hwee Lawrence QuekTan Tock Seng Hospital, Singapore 308433, Singapore.
Cher Heng TanWoodlands Hospital, Singapore 737628, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnetic Resonance Imaging (MRI) plays a pivotal role in evaluating treatment response following radiation-based therapies for hepatocellular carcinoma (HCC). As radiation modalities such as stereotactic body radiotherapy (SBRT) and transarterial radioembolization (TARE) gain prominence, understanding the underlying mechanisms of radiation-induced cellular senescence is essential for accurate interpretation of imaging. The physiological changes of radiation treatment manifest as altered diffusion characteristics and delayed regression of enhancement and tumor volumes on MRI, challenging conventional response criteria. Herein, functional and temporal imaging biomarkers are necessary. However, current imaging strategies lack standardization and robust validation, underscoring the need for prospective studies to correlate MRI findings with treatment outcomes. This review synthesizes emerging evidence on MRI-based evaluation of radiation-treated HCC, explores the physiological rationale linking senescence to imaging phenotypes, and advocates for optimized imaging protocols and criteria to enhance post-treatment surveillance and therapeutic decision-making.

Indexed as

hepatocellular carcinomasenescenceTAREtransarterial radioembolizationtreatment response

Identifiers

PMID41976312
PMCPMC13072226

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.