Evidence map›Paper›PMID 41976309›Full record

ArticleCancers2026

Blu-Ray-Based Quantification of CD98+ Extracellular Vesicles for Early Detection of Hepatocellular Carcinoma.

Su-Liang Chen, Yong Seng Low, Bo-Ru Huang, Che-Hao Lu, Wei-Chun Lan, Ren-Huang Wu, Hsing-Ying Lin, Andrew Yueh, En-Chi Hsu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Su-Liang ChenInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli County 350, Taiwan.ORCID 0009-0005-8043-4398
Yong Seng LowInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli County 350, Taiwan.
Bo-Ru HuangInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli County 350, Taiwan.
Che-Hao LuInstitute of Biomedical Engineering, National Tsing-Hua University, Hsinchu City 300, Taiwan.
Wei-Chun LanInstitute of Biomedical Engineering, National Tsing-Hua University, Hsinchu City 300, Taiwan.
Ren-Huang WuInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350, Taiwan.
Hsing-Ying LinInstitute of Biomedical Engineering, National Tsing-Hua University, Hsinchu City 300, Taiwan.
Andrew YuehInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350, Taiwan.
En-Chi HsuInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli County 350, Taiwan.ORCID 0000-0002-5671-6169

Funding

National Health Research Institutes Project MG-111-PP-16, MG-112-PP-16, and MG-113-PP-16National Science and Technology Council Project NSTC111-2320-B400-027 and NSTC113-2320-B400-027
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) remains a major global health burden, with an increasing incidence driven by metabolic syndrome-related cases. Early detection is critical; however, current diagnostic tools, including ultrasonography and alpha-fetoprotein (AFP), lack adequate sensitivity and specificity, particularly for non-viral HCC. In this "discovery-stage" study, we identified CD98, a transmembrane oncoprotein, as a robust biomarker highly expressed across all HCC stages, independent of etiological factors. CD98 is enriched on extracellular vesicles (EVs) released by HCC cells and can be accurately quantified using Blu-ray-based ExoCounter technology. In plasma samples from patients with early-stage (stage I/II) non-viral HCC (

Indexed as

cancer early detectionCD98exocounter technologyextracellular vesicleshepatocellular carcinoma

Identifiers

PMID41976309
PMCPMC13072036

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.