Evidence map›Paper›PMID 41976298›Full record

ReviewCancers2026

DNA Methylation in Gastric Cancer and Preneoplastic Lesions: Emerging Insights and Future Directions.

Carlotta Ceccon, Giulia Maddalena, Valentina Angerilli, Floriana Nappo, Jessica Gasparello, Marianna Sabbadin, Luisa Toffolatti, Francesca Bergamo, Matteo Fassan, Sara Lonardi

Abstract readReview
In one paragraph

Review in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carlotta CecconDepartment of Surgery, Oncology and Gastroenterology, University of Padua, 35128 Padua, Italy.ORCID 0009-0004-5478-9550
Giulia MaddalenaVeneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Valentina AngerilliSurgical Pathology Unit, ULSS2 Marca Trevigiana, 31100 Treviso, Italy.
Floriana NappoVeneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.ORCID 0000-0002-1319-6052
Jessica GasparelloDepartment of Medicine, Surgical Pathology Unit, University of Padua, 35128 Padua, Italy.
Marianna SabbadinSurgical Pathology Unit, ULSS2 Marca Trevigiana, 31100 Treviso, Italy.
Luisa ToffolattiSurgical Pathology Unit, ULSS2 Marca Trevigiana, 31100 Treviso, Italy.
Francesca BergamoVeneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Matteo FassanSurgical Pathology Unit, ULSS2 Marca Trevigiana, 31100 Treviso, Italy.ORCID 0000-0001-6515-5482
Sara LonardiVeneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.ORCID 0000-0002-7593-8138

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC) represents one of the most common and lethal cancers worldwide. The lack of early detection methods and wide heterogeneity from both histopathological and molecular points of view contribute to the high mortality associated with GC. Nowadays, the growing interest in the epigenetic landscape appears to represent a promising approach for improving early diagnosis, disease monitoring, therapy selection, and drug response. The knowledge of the epigenetic landscape in cancerous and, especially in precancerous lesions, remain scarce and controversial. The limitations must be identified due to the lack of standardization in experimental settings which introduce bias and lead to discrepancies in final conclusions. This review aims to provide an overview of epigenetics in the diagnostic setting of gastric cancer and in preneoplastic conditions, illustrating the available experimental approaches and therapeutic management in the era of epigenetics.

Indexed as

DNA methylationepigenetic biomarkersgastric cancerprecancerous gastric lesionsprecision oncologytarget therapy

Identifiers

PMID41976298
PMCPMC13072113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.